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St Johns wort increases expression of P-glycoprotein: implications for drug interactions.
Author: BackD, BarryM, FeelyJ, HennessyMartina, KavanaghP, KelleherD, MulcahyF, SpiersJ P
Original Abstract of the Article :
St John's Wort (SJW) is widely used in the treatment of depression but concerns have been raised about its potential to interact with other drugs. Co-administration with SJW has resulted in significant reductions in trough plasma concentrations of indinavir and cyclosporin [1, 2]. Induction of cytoc...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1046/j.0306-5251.2001.01516.x
データ提供:米国国立医学図書館(NLM)
St. John's Wort and Drug Interactions
St. John's Wort (SJW) is a popular herbal remedy often used for treating depression. However, concerns have been raised about its potential to interact with other medications. This research investigates the mechanisms underlying these drug interactions, focusing on the role of P-glycoprotein, a transporter protein involved in drug metabolism. The study examines the impact of SJW on P-glycoprotein expression and function, suggesting that it may contribute to the development of potentially harmful drug-drug interactions.
SJW and Drug Interactions
The research suggests that SJW's effect on P-glycoprotein expression may contribute to the observed drug interactions. This finding highlights the importance of considering potential drug interactions when using SJW, especially for individuals taking other medications.
Navigating the Desert of Drug Interactions
This research serves as a reminder that even seemingly natural remedies can have significant interactions with other medications. It emphasizes the need for careful consideration of drug interactions, especially for patients taking multiple medications or herbal supplements. It's like navigating a vast desert, where seemingly harmless plants can harbor hidden dangers. It's crucial to consult healthcare providers about potential interactions between medications and herbal remedies.
Dr.Camel's Conclusion
This research is a reminder that the desert of medicine is filled with intricate connections, and seemingly simple remedies can have complex effects. The study underscores the importance of being mindful of potential drug interactions, especially when using herbal remedies alongside conventional medications. It's a journey that requires vigilance and a careful understanding of the intricacies of the human body.
Date :
- Date Completed 2002-04-23
- Date Revised 2019-05-13
Further Info :
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