Primary chemoprevention of familial adenomatous polyposis with sulindac.

Author: GarrettElizabeth, GeimanDeborah E, GiardielloFrancis M, HamiltonStanley R, HubbardWalter, HylindLinda M, KrushAnne J, OfferhausG Johan A, PetersenGloria M, PiantadosiSteven, TrimbathJill D, YangVincent W

Paper Details 
Original Abstract of the Article :
Familial adenomatous polyposis is caused by a germ-line mutation in the adenomatous polyposis coli gene and is characterized by the development of hundreds of colorectal adenomas and, eventually, colorectal cancer. Nonsteroidal antiinflammatory drugs can cause regression of adenomas, but whether the...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/11932472

データ提供:米国国立医学図書館(NLM)

Sulindac for Familial Adenomatous Polyposis: A Promising Avenue for Prevention

Familial adenomatous polyposis (FAP), a genetic condition that predisposes individuals to the development of hundreds of colorectal adenomas, is like a desert oasis, where a seemingly idyllic setting harbors a hidden threat. This study investigates the potential for sulindac, a nonsteroidal anti-inflammatory drug, to prevent the formation of adenomas in individuals with FAP. The researchers, like intrepid explorers seeking to tame the desert’s dangers, embarked on a quest to understand the preventative potential of sulindac.

Sulindac’s Potential for Adenoma Prevention: A Promising Discovery

The study, like a well-placed oasis in a treacherous desert, highlights the potential for sulindac to prevent adenoma formation in individuals with FAP. While previous studies have shown that sulindac can cause regression of existing adenomas, this research explored its preventative capabilities. The study’s findings provide a promising avenue for preventing the development of adenomas in individuals at risk for FAP, offering a potential path to a healthier future.

A Glimmer of Hope for FAP Patients: Potential for Early Intervention

This research, like a beacon in the desert, offers a glimmer of hope for individuals with FAP. The study’s findings suggest that sulindac has the potential to prevent the formation of adenomas, offering a potential strategy for early intervention and reducing the risk of colorectal cancer.

Dr.Camel's Conclusion

This study, like a well-charted path through a challenging desert, explores the potential of sulindac to prevent adenoma formation in individuals with FAP. The study’s findings offer a beacon of hope for a healthier future, encouraging further research into the use of sulindac as a preventive measure for FAP.

Date :
  1. Date Completed 2002-04-16
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

11932472

DOI: Digital Object Identifier

NIHMS38261

Related Literature

SNS
PICO Info
in preparation
Languages

English

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