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Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure.

Author: CullenP T, KocherH M, LeatherA J M, StewardM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Diltiazem hydrochloride (DTZ) cream was more effective than glyceryl trinitrate (GTN) ointment in treating chronic anal fissure with fewer headaches as a side effect. The healing rate was similar in both treatments.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Glyceryl trinitrate (GTN) ointment (0 small middle dot2 per cent) has an efficacy of up to 68 per cent in healing chronic anal fissure, but with headache as a major side-effect. Diltiazem hydrochloride (DTZ) cream (2 per cent) is expected to have fewer side-effects. METHODS: A prospec...See full text at original site
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引用元：
https://doi.org/10.1046/j.0007-1323.2001.02042.x

データ提供：米国国立医学図書館（NLM）

Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure

This study compares the incidence of side effects associated with glyceryl trinitrate (GTN) ointment and diltiazem hydrochloride (DTZ) cream in the treatment of chronic anal fissure. The researchers found that DTZ cream caused significantly fewer headaches than GTN ointment, while both treatments demonstrated comparable healing rates. This finding suggests that DTZ might be the preferred first-line treatment for chronic anal fissure.

Diltiazem: A potential oasis in the desert of anal fissure treatment

This study highlights the potential benefits of DTZ cream in managing chronic anal fissure. The findings suggest that DTZ may be a better option than GTN ointment, offering similar healing rates with fewer side effects.

Navigating the landscape of anal fissure treatment

As a wise camel, I understand the importance of finding a comfortable path through the desert of discomfort. This study offers valuable insights into the management of chronic anal fissure. It is crucial to consult with a healthcare professional to determine the most appropriate treatment plan, taking into account individual needs and potential risks and benefits.

Dr.Camel's Conclusion

The study demonstrates the efficacy and safety of diltiazem hydrochloride cream in the treatment of chronic anal fissure, suggesting that it may be a better option than glyceryl trinitrate ointment due to its lower incidence of headaches. The findings provide valuable information for clinicians and patients seeking effective and well-tolerated treatment for this condition.

Date :
  1. Date Completed 2002-05-23
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

11952579

DOI: Digital Object Identifier

10.1046/j.0007-1323.2001.02042.x

Related Literature

Article Analysis
・Side Effects of diltiazem
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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