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Pneumococcal polysaccharide vaccine: a systematic review of clinical effectiveness in adults.

Author: WatsonLorna, WaughNorman, WilsonBrenda J

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Pneumococcal vaccination showed no benefit in industrialised populations other than for pneumococcal bacteraemia. Clear benefit was demonstrated for mortality and all-cause pneumonia in non-industrial populations.
Paper Details　
Original Abstract of the Article :
UNLABELLED: Pneumococcal polysaccharide vaccine is recommended in western countries for individuals at high risk of pneumococcal illness. We undertook a systematic review of randomised controlled trials of pneumococcal vaccine in adults, to determine the effects on clinical outcomes. RESULTS: In in...See full text at original site
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引用元：
https://doi.org/10.1016/s0264-410x(02)00112-3

データ提供：米国国立医学図書館（NLM）

Pneumococcal Vaccination: A Shield Against a Desert Disease

Pneumococcal disease is a serious infection caused by bacteria known as Streptococcus pneumoniae. This study examines the effectiveness of pneumococcal polysaccharide vaccine (PPSV) in protecting adults from pneumococcal illness. The researchers conducted a systematic review of randomized controlled trials to assess the impact of PPSV on various clinical outcomes, comparing its effects in different populations. The study aimed to evaluate the effectiveness of PPSV in adults, particularly in different population settings. This study explored the effectiveness of pneumococcal polysaccharide vaccine (PPSV) in adults, seeking to determine its impact on clinical outcomes in different population settings.

PPSV: A Valuable Tool for Preventing Pneumococcal Disease

The study found that PPSV was effective in reducing the risk of pneumococcal bacteremia, a serious bloodstream infection, in industrialized populations. However, there was limited evidence for other clinical benefits, such as reduced rates of pneumonia. In contrast, the study found a clear benefit of PPSV in non-industrialized populations, demonstrating a reduction in mortality and all-cause pneumonia. The study highlights the importance of considering the baseline risk of infection and the specific characteristics of a given population when evaluating the effectiveness of PPSV.

A Desert of Vulnerability: Understanding the Risk of Pneumococcal Disease

The findings of this study underscore the importance of targeted vaccination strategies to address the varying risks of pneumococcal disease in different populations. PPSV can be a valuable tool for protecting individuals at high risk of pneumococcal infection. This study highlights the need for ongoing research and evaluation of vaccination programs to ensure their effectiveness and optimize their impact on public health.

Dr. Camel's Conclusion

Pneumococcal disease is a threat lurking in the desert of human health. PPSV, like a well-equipped caravan, can provide protection against this dangerous foe. The study emphasizes the importance of understanding the unique needs of different populations when implementing vaccination strategies, ensuring that we can protect those most vulnerable to pneumococcal disease.

Date :
  1. Date Completed 2002-12-31
  2. Date Revised 2019-07-28
Further Info :

Pubmed ID

12009269

DOI: Digital Object Identifier

10.1016/s0264-410x(02)00112-3

SNS
PICO Info
in preparation
Languages

English

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