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A randomized, controlled, double-blind trial comparing two loading doses of aminophylline.

Author: ChangJocelin, HochwaldChristine, KennedyKathleen, MoyaFernando

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared 8 mg/kg and 6 mg/kg loading doses of aminophylline in 61 preterm infants weighing <1500 g. The 8 mg/kg group achieved recommended serum theophylline levels (7-12 microg/ml) more frequently than the 6 mg/kg group (39% vs 3%, p=0.002). There were no increases in side effects with the higher loading dose. The use of an 8 mg/kg loading dose appears to be a better and safe way to quickly achieve serum theophylline levels within the recommended range.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To compare 8 mg/kg and 6 mg/kg loading doses of aminophylline. STUDY DESIGN: Sixty-one preterm infants weighing <1500 g were enrolled once a decision to administer intravenous aminophylline was made. A standard maintenance dose was used. Serum levels of theophylline were drawn 8 hours af...See full text at original site
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引用元：
https://doi.org/10.1038/sj.jp.7210737

データ提供：米国国立医学図書館（NLM）

Finding the Right Dose: Navigating the Desert of Preterm Infant Care

Preterm infants often require special care, like a camel navigating a desert with limited resources. This study explores the optimal loading dose of aminophylline, a medication used to treat respiratory problems in these fragile newborns.

Optimal Aminophylline Loading Dose for Preterm Infants

The study found that a higher loading dose of aminophylline (8mg/kg) was more effective in achieving therapeutic serum levels in preterm infants compared to a lower dose (6mg/kg). This is like finding the right amount of water to replenish a camel's thirst in the desert - it's crucial for optimal health and recovery.

Ensuring Safe and Effective Treatment for Preterm Infants

This research emphasizes the importance of finding the right dose for medications in preterm infants. The study found that a higher loading dose was safe and effective in achieving therapeutic levels. This is crucial for ensuring the best possible care for these vulnerable newborns. It's a reminder that even in the most challenging of circumstances, finding the right solution can make a world of difference.

Dr.Camel's Conclusion

This study offers valuable guidance for the safe and effective treatment of preterm infants. The findings suggest that a higher loading dose of aminophylline can achieve therapeutic levels more effectively, leading to better outcomes for these vulnerable newborns. This research is a beacon of hope in the desert of neonatal care, offering a potential solution to improve the well-being of these precious little ones.

Date :
  1. Date Completed 2002-07-18
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

12032788

DOI: Digital Object Identifier

10.1038/sj.jp.7210737

Related Literature

Article Analysis
・Side Effects of aminophylline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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