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Protective effects of dextromethorphan and tizanidine on ouabain-induced arrhythmias.

Author: OzekM, SevgiS, UresinY

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of dextromethorphan, an opioid agonist, and tizanidine, an alpha 2-adrenoceptor agonist, on ouabain-induced cardiac arrhythmias in rats. Both drugs were found to reduce the incidence of arrhythmias, suggesting they might possess antiarrhythmic actions through both central and peripheral mechanisms.
Paper Details　
Original Abstract of the Article :
The effects of the opioid agonist dextromethorphan and the alpha 2-adrenoceptor agonist tizanidine on ouabain-induced cardiac arrhythmias were investigated in rats. Ouabain (10 mg/kg i.v.) elicited ventricular arrhythmias in all of the control rats. Administration of dextromethorphan (25 mg/kg i.v.)...See full text at original site
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引用元：
https://doi.org/10.1358/mf.2002.24.7.696543

データ提供：米国国立医学図書館（NLM）

Protecting Hearts from Ouabain-Induced Arrhythmias

The beating of a heart is a delicate dance, and any disruption to its rhythm can be dangerous. This study investigates the protective effects of dextromethorphan and tizanidine against ouabain-induced cardiac arrhythmias in rats. The researchers focused on exploring how these drugs could mitigate the potentially deadly disruptions to the heart's rhythm.

Dextromethorphan and Tizanidine: Protective Agents Against Arrhythmias

The study found that both dextromethorphan and tizanidine significantly reduced the incidence of arrhythmias induced by ouabain. This is like finding a cool oasis in the midst of a scorching desert, providing relief and protection for the delicate heart. The authors suggest that these drugs work by reducing the activity of excitatory amino acids, which play a critical role in the development of arrhythmias.

Understanding the Mechanisms of Heart Protection

These findings highlight the importance of understanding the intricate mechanisms that regulate heart function. By delving into the roles of various molecules like excitatory amino acids, we can develop more effective strategies for preventing and treating heart arrhythmias. This research could pave the way for future discoveries that will save lives.

Dr. Camel's Conclusion

This study shows that dextromethorphan and tizanidine could provide valuable protection against ouabain-induced arrhythmias. It's like finding two sturdy camels in the desert, providing support and stability during a perilous journey. This research is a reminder that we must continue to explore the desert of cardiovascular science, seeking new oases of knowledge that will improve heart health.

Date :
  1. Date Completed 2003-05-20
  2. Date Revised 2019-11-06
Further Info :

Pubmed ID

12428430

DOI: Digital Object Identifier

10.1358/mf.2002.24.7.696543

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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