Paper Details 
Original Abstract of the Article :
The effects of the nonsteroidal antiandrogen bicalutamide (Casodex(TM)) and the luteinizing hormone releasing hormone agonist leuprolide depot (Procren Depot(TM), Lupron Depot(TM)) on serum prostate-specific antigen (PSA), acid phosphatase (ACP), and prostatic acid phosphatase (PAP) in patients with...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/12497037

データ提供:米国国立医学図書館(NLM)

Effects of Bicalutamide and Leuprolide on Prostate-Specific Antigen

This study examines the effects of bicalutamide and leuprolide, two medications used to suppress androgen production, on serum prostate-specific antigen (PSA), acid phosphatase (ACP), and prostatic acid phosphatase (PAP) in patients with benign prostatic hyperplasia (BPH). The study involved two separate groups of patients, one receiving bicalutamide and the other receiving leuprolide. The researchers found that both bicalutamide and leuprolide significantly reduced serum PSA levels. However, leuprolide induced a more pronounced decline in PSA levels compared to bicalutamide. The study also found that leuprolide significantly reduced PAP levels while bicalutamide did not.

Androgen Suppression: Targeting Prostate Health

The study's findings provide insights into the effects of androgen suppression on PSA levels in patients with BPH. The study's results suggest that both bicalutamide and leuprolide effectively reduce PSA levels, indicating their potential as treatment options for BPH. However, the study also suggests that leuprolide may be more potent in suppressing PSA production compared to bicalutamide.

Navigating Prostate Health: A Multi-faceted Approach

The desert landscape is a tapestry of different terrains, each with its own unique challenges. Similarly, managing prostate health requires a multi-faceted approach, considering the specific needs of each individual. This study highlights the importance of understanding the different effects of androgen suppression on PSA levels, guiding treatment decisions and optimizing outcomes for patients with BPH.

Dr. Camel's Conclusion

This study underscores the need for ongoing research to understand the complex interplay between androgen suppression, PSA levels, and prostate health. The study's findings highlight the need for careful monitoring and evaluation of PSA levels in patients receiving androgen suppression therapy for BPH, ensuring that they receive the most appropriate and effective treatment.
Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

12497037

DOI: Digital Object Identifier

4500504

Related Literature

SNS
PICO Info
in preparation
Languages

English

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