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Comparative effects of rosuvastatin and atorvastatin across their dose ranges in patients with hypercholesterolemia and without active arterial disease.

Author: BallantyneChristie M, ChitraRohini R, KnoppRobert H, McPhersonRuth, SchneckDennis W, SimonsonSteven G

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Rosuvastatin was more effective than atorvastatin in lowering LDL cholesterol across a range of doses. Rosuvastatin also resulted in greater decreases in total cholesterol, non-HDL cholesterol, and apolipoprotein B. Both drugs were well tolerated.
Paper Details　
Original Abstract of the Article :
The lipid-lowering effects of rosuvastatin and atorvastatin were determined across their dose ranges in a 6-week, randomized, double-blind trial. Three hundred seventy-four hypercholesterolemic patients with fasting low-density lipoprotein (LDL) cholesterol > or =160 but <250 mg/dl (> or =4.14 but <...See full text at original site
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引用元：
https://doi.org/10.1016/s0002-9149(02)02994-6

データ提供：米国国立医学図書館（NLM）

Rosuvastatin vs. Atorvastatin: A Race Through the Desert of Cholesterol Management

The vast desert of hypercholesterolemia often presents us with the challenge of finding effective and safe treatments to lower cholesterol levels. This research, situated within the realm of [Cardiology and Lipidology], investigates the lipid-lowering effects of [rosuvastatin] and [atorvastatin], two statin medications, across their respective dose ranges. The study's objective was to compare the efficacy of these drugs in lowering LDL cholesterol and other lipid parameters. The researchers found that [rosuvastatin] demonstrated [significantly greater reductions] in LDL cholesterol and other lipid parameters compared to [atorvastatin] at all doses, suggesting a potential advantage for this drug in managing hypercholesterolemia. This study could lead to a better understanding of the specific effects of different statin medications, providing a valuable roadmap for navigating the desert of cholesterol management.

A Winning Race Through the Desert of Cholesterol

This study offers valuable insights into the lipid-lowering effects of rosuvastatin and atorvastatin, two commonly used statin medications. The researchers' findings suggest that rosuvastatin demonstrates significantly greater reductions in LDL cholesterol and other lipid parameters compared to atorvastatin at all doses. This discovery could lead to a more targeted approach to managing hypercholesterolemia, offering a potential oasis of hope in the desert of cholesterol management.

Navigating the Desert of Cholesterol Management with Statins

The study's findings highlight the importance of considering the specific needs of each patient when choosing a statin medication. Rosuvastatin, a drug commonly used for hypercholesterolemia, may offer a greater reduction in LDL cholesterol and other lipid parameters compared to atorvastatin. As a healthcare professional, I would recommend discussing the best treatment options with your physician, considering your individual needs and potential benefits. Together, we can navigate the desert of cholesterol management with a clearer path towards a healthier future.

Dr.Camel's Conclusion

This study offers valuable insights into the lipid-lowering effects of rosuvastatin and atorvastatin, two commonly used statin medications. The researchers' findings suggest that rosuvastatin demonstrates significantly greater reductions in LDL cholesterol and other lipid parameters compared to atorvastatin at all doses. This discovery could lead to a more targeted approach to managing hypercholesterolemia, offering a potential oasis of hope in the desert of cholesterol management.
Date :
  1. Date Completed 2003-02-06
  2. Date Revised 2019-06-23
Further Info :

Pubmed ID

12505568

DOI: Digital Object Identifier

10.1016/s0002-9149(02)02994-6

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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