Effect of chelation therapy on endothelial function in patients with coronary artery disease: PATCH substudy.

Author: AndersonTodd J, HubacekJaroslav, KnudtsonMerril L, WyseD George

Paper Details 
Original Abstract of the Article :
OBJECTIVES: The purpose of this study was to evaluate the effect of chelation therapy with ethylenediamine tetraacetic acid (EDTA) on endothelium-dependent vasomotor responses in patients with documented coronary artery disease (CAD). BACKGROUND: Oxidative stress plays an important role in the dysf...See full text at original site
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引用元:
https://doi.org/10.1016/s0735-1097(02)02770-5

データ提供:米国国立医学図書館(NLM)

Chelation Therapy and Endothelial Function: A Search for Enhanced Cardiovascular Health

This research explores the potential benefits of chelation therapy, a treatment that involves removing heavy metals from the body, in improving endothelial function, a critical aspect of cardiovascular health. The study focuses on patients with coronary artery disease (CAD), a condition characterized by narrowing of the arteries that supply blood to the heart. The researchers investigate the effects of chelation therapy with ethylenediamine tetraacetic acid (EDTA), a common chelating agent, on endothelium-dependent brachial artery flow-mediated vasodilation (FMD), a measure of endothelial function. The study involved 47 patients with CAD who were randomly assigned to receive either chelation therapy or a placebo. The researchers measured FMD at baseline and after 6 months of treatment. The results indicated no significant difference in FMD between the chelation therapy group and the placebo group.

Chelation Therapy and Cardiovascular Health: A Complex Relationship

This study provides valuable insights into the potential of chelation therapy in improving cardiovascular health. The researchers demonstrate that chelation therapy with EDTA, in combination with vitamins and minerals, does not provide additional benefits beyond standard treatments for atherosclerotic risk factors. Just as a desert oasis can only provide sustenance if it has reliable water sources, chelation therapy may not be a miracle cure for cardiovascular disease without addressing underlying risk factors.

Cardiovascular Health: A Multifaceted Approach

This study underscores the importance of a multifaceted approach to managing cardiovascular health. The researchers highlight the need for comprehensive management strategies that address all modifiable risk factors, including lifestyle changes, medications, and other evidence-based treatments. Just as a desert ecosystem requires a complex web of interacting elements to thrive, our cardiovascular health is influenced by a range of factors.

Dr. Camel's Conclusion

This study provides evidence that chelation therapy with EDTA does not offer additional benefits beyond standard treatments for cardiovascular disease. The researchers emphasize the need for comprehensive management strategies that address all modifiable risk factors. While chelation therapy may hold some promise in certain situations, it's crucial to rely on evidence-based practices and address the root causes of cardiovascular disease for optimal outcomes.

Date :
  1. Date Completed 2003-02-25
  2. Date Revised 2019-07-08
Further Info :

Pubmed ID

12575969

DOI: Digital Object Identifier

10.1016/s0735-1097(02)02770-5

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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