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A randomized, double-blind, placebo-controlled, multicenter study that assessed the endometrial effects of norethindrone acetate plus ethinyl estradiol versus ethinyl estradiol alone.

Author: KempfertNona J, PortmanDavid J, SymonsJames P, WilbornWalter

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Norethindrone acetate effectively protects the endometrium from estrogen-induced hyperplasia. Norethindrone acetate/ethinyl estradiol combinations also significantly reduce endometrial proliferation compared to conjugated equine estrogens/medroxyprogesterone acetate.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The purpose of this study was to determine the incidence of endometrial hyperplasia in subjects who receive continuous norethindrone acetate and ethinyl estradiol combinations versus unopposed ethinyl estradiol. STUDY DESIGN: Nine hundred forty-five postmenopausal women were randomly sel...See full text at original site
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引用元：
https://doi.org/10.1067/mob.2003.91

データ提供：米国国立医学図書館（NLM）

Protecting the Endometrium: Investigating the Effects of Hormone Therapy

Hormone therapy is a complex topic, with ongoing research focused on understanding its long-term effects. This study delves into the endometrial effects of different hormone combinations, specifically norethindrone acetate and ethinyl estradiol, in postmenopausal women. Researchers compared the incidence of endometrial hyperplasia in women receiving continuous combined therapy versus those receiving unopposed ethinyl estradiol. The study's findings shed light on the protective role of norethindrone acetate in preventing estrogen-induced endometrial hyperplasia and highlight the importance of careful consideration of hormone therapy regimens in postmenopausal women.

Norethindrone Acetate: A Shield for the Endometrium

The study demonstrates the protective effects of norethindrone acetate on the endometrium. The researchers found that norethindrone acetate significantly reduced the incidence of endometrial hyperplasia and proliferation, suggesting a beneficial role in protecting the endometrium from estrogen-induced changes.

Balancing Hormones: Weighing the Benefits and Risks

This study underscores the importance of personalized hormone therapy, tailored to the individual needs and risks of each patient. The research highlights the potential benefits of norethindrone acetate in protecting the endometrium, but it's crucial to discuss the potential risks and benefits of hormone therapy with your healthcare provider.

Dr.Camel's Conclusion

This study provides valuable insights into the endometrial effects of hormone therapy, showcasing the potential protective role of norethindrone acetate in reducing the risk of estrogen-induced hyperplasia.

Date :
  1. Date Completed 2003-03-27
  2. Date Revised 2019-06-16
Further Info :

Pubmed ID

12592236

DOI: Digital Object Identifier

10.1067/mob.2003.91

Related Literature

Article Analysis
・Effects of norethindrone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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