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Sensitivity to the effects of opioids in rats with free access to exercise wheels: mu-opioid tolerance and physical dependence.

Author: SmithMark A, YanceyDavid L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study investigates the possibility that exercise may lead to the development of cross-tolerance to exogenously administered opioid agonists.
Paper Details　
Original Abstract of the Article :
Exercise stimulates the release of endogenous opioid peptides and increases nociceptive (i.e. pain) thresholds in both human and animal subjects. During chronic, long-term exercise, sensitivity to the effects of morphine and other mu opioids decreases, leading some investigators to propose that exer...See full text at original site
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引用元：
https://doi.org/10.1007/s00213-003-1471-5

データ提供：米国国立医学図書館（NLM）

Exercise and Opioids: A Complex Relationship

This study investigated the effects of exercise on opioid sensitivity in rats. The researchers found that rats with free access to exercise wheels developed tolerance to morphine and showed decreased sensitivity to the effects of opioids. This suggests that exercise may induce cross-tolerance to opioid agonists, potentially impacting pain management strategies.

Exercise, Opioids, and Pain: A Balancing Act

This study raises interesting questions about the complex interplay between exercise, opioid sensitivity, and pain management. The findings suggest that regular exercise may lead to tolerance to opioid agonists, potentially impacting the effectiveness of pain relief strategies. This underscores the importance of considering individual exercise habits and opioid use patterns when managing pain.

Understanding Exercise and Pain Management: Individualized Approaches

The study highlights the need for individualised approaches to pain management, taking into account a patient's exercise habits and opioid use patterns. While exercise offers numerous health benefits, it may also influence opioid sensitivity, potentially affecting the effectiveness of pain relief strategies. This emphasizes the importance of open communication between patients and healthcare providers to tailor treatment plans to individual needs.

Dr. Camel's Conclusion

The relationship between exercise, opioids, and pain is complex and multifaceted. Just as a desert traveler must adapt to changing conditions, understanding the interplay between exercise, opioid sensitivity, and pain management is crucial for optimal health outcomes. This study reminds us that individualized approaches are key to effectively managing pain and promoting overall well-being.

Date :
  1. Date Completed 2003-12-24
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

12709780

DOI: Digital Object Identifier

10.1007/s00213-003-1471-5

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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