Paper Details

  1. Home
  2. Paper Details

High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma.

Author: , BellSusan E, BrownJulia, ChildJ Anthony, DaviesFaith E, DraysonMark T, HawkinsKim, MorganGareth J, OwenRoger G, SelbyPeter J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

High-dose chemotherapy with stem cell transplantation is a treatment option for cancer, but its effectiveness is debated. While this approach leads to higher remission rates for multiple myeloma compared to standard chemotherapy, it is unclear if it improves long-term survival.
Paper Details　
Original Abstract of the Article :
High-dose therapy with supporting autologous stem-cell transplantation remains a controversial treatment for cancer. In multiple myeloma, first-line regimens incorporating high-dose therapy yield higher remission rates than do conventional-dose treatments, but evidence that this translates into impr...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/12736280

データ提供：米国国立医学図書館（NLM）

High-Dose Chemotherapy for Multiple Myeloma: A Controversial Approach

In the vast and ever-evolving field of cancer treatment, one of the most hotly debated topics is the use of high-dose chemotherapy followed by a stem cell transplant. This approach involves administering a powerful dose of chemotherapy to kill cancer cells, followed by the transplantation of healthy stem cells to help rebuild the immune system. This research investigates the effectiveness of this strategy in treating multiple myeloma, a type of blood cancer.

The study examined the results of different chemotherapy regimens, some using high doses and others employing conventional doses. The researchers found that high-dose therapy did lead to higher remission rates, meaning more patients experienced a temporary or complete disappearance of their cancer. However, the evidence for improved survival in these patients was limited.

Remission, But Not Necessarily a Cure

While the results suggest that high-dose chemotherapy may be effective in achieving remission, its impact on long-term survival remains unclear. This is a crucial point to consider, as the side effects of high-dose therapy can be quite severe.

A Careful Balancing Act

The findings highlight the need for a careful balancing act when considering high-dose chemotherapy for multiple myeloma. Just as a camel carefully navigates the shifting sands of the desert, doctors must weigh the potential benefits against the risks associated with this treatment. It's essential to have open and honest conversations with patients about their individual circumstances and goals, ensuring that their treatment plan is tailored to their specific needs.

Dr.Camel's Conclusion

High-dose chemotherapy for multiple myeloma remains a controversial treatment. It is essential to weigh the potential benefits against the risks, and to ensure that the treatment plan is tailored to the individual patient's needs.

Date :
  1. Date Completed 2003-05-14
  2. Date Revised 2022-04-20
Further Info :

Pubmed ID

12736280

DOI: Digital Object Identifier

348/19/1875

Related Literature

Article Analysis
・Effective treatment of multiple myeloma
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.