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[Comparative effectiveness of lotensin and capoten in patients with chronic cardiac failure].

Author: LiV V, SuvorovaS S, TimofeevaN Iu, ZadionchenkoV S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Both captopril and benazepril are effective in treating chronic cardiac failure (CCF) with improvement in functional class, exercise tolerance, platelet aggregation, and reduced arrhythmia and myocardial ischemia episodes. Long-term treatment with benazepril shows further improvement in clinical and laboratory indices.
Paper Details　
Original Abstract of the Article :
AIM: To compare clinical response to captopril (capoten) vs benazepril (lotensin) in patients with chronic cardiac failure (CCF) as well as their influence on central hemodynamics, some indices of platelet hemostasis, myocardial ischemia degree, exercise tolerance. MATERIAL AND METHODS: 54 patients...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12793140

データ提供：米国国立医学図書館（NLM）

A Heartfelt Battle: Comparing Lotensin and Capoten in Chronic Cardiac Failure

Chronic cardiac failure, a debilitating condition that weakens the heart's ability to pump blood efficiently, is a formidable foe in the world of cardiovascular disease. This study seeks to compare the effectiveness of two medications, captopril (Capoten) and benazepril (Lotensin), in treating patients with chronic cardiac failure. The researchers meticulously recruited 54 patients, dividing them into two groups – one receiving captopril and the other receiving benazepril. They then carefully monitored the patients' clinical response, analyzing key indicators such as functional class, exercise tolerance, platelet aggregation, and the frequency of arrhythmias and myocardial ischemia episodes.

A Journey of Improvement: Analyzing the Effectiveness of Both Medications

Both captopril and benazepril demonstrated positive effects, improving functional class, exercise tolerance, and platelet aggregation while reducing the frequency of arrhythmias and myocardial ischemia episodes. However, lotensin emerged as a potential frontrunner, leading to further improvements in clinical and laboratory indices over the long term. Importantly, lotensin was more effective in reducing episodes of ST expression on ECG and episodes of painless myocardial ischemia, highlighting a potentially significant advantage in managing specific cardiac complications.

A Path to Better Heart Health: Navigating Treatment Choices

This study offers valuable insights for healthcare professionals seeking to optimize treatment for patients with chronic cardiac failure. By carefully evaluating the relative benefits of captopril and lotensin, clinicians can make informed decisions tailored to each patient's unique needs. It's a reminder that in the challenging landscape of cardiovascular disease, finding the right path for each patient is crucial for achieving the best possible outcomes.

Dr. Camel's Conclusion

This research, much like a caravan crossing a vast desert, offers a roadmap for navigating the complexities of chronic cardiac failure treatment. It highlights the importance of tailored treatment strategies and offers hope for better outcomes for patients with this challenging condition.
Date :
  1. Date Completed 2003-08-01
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

12793140

DOI: Digital Object Identifier

12793140

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Languages

Russian

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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