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Additive effects of dipyridamole and Trolox in protecting human red cells during photodynamic treatment.

Author: BesselinkG A J, EbbingI G, HilariusP M, VerhoevenA J, de KorteD, van EngelenburgF A C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study explored the potential of dipyridamole and Trolox to protect red blood cells (RBCs) from the harmful side-effects of photodynamic treatment.
Paper Details　
Original Abstract of the Article :
Photodynamic treatment (PDT) of red blood cell (RBC) suspensions has been reported to result in virus inactivation, but also in deterioration of cell quality. Recently, we have demonstrated the potential usefulness of the reactive oxygen species scavenger dipyridamole in selectively protecting RBCs ...See full text at original site
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引用元：
https://doi.org/10.1046/j.1423-0410.2003.00318.x

データ提供：米国国立医学図書館（NLM）

Additive effects of dipyridamole and Trolox in protecting human red cells during photodynamic treatment

This study investigates the potential of combining dipyridamole, a reactive oxygen species scavenger, with Trolox, a hydrophilic vitamin E analogue, to enhance the protection of human red blood cells (RBCs) during photodynamic treatment (PDT). The authors found that dipyridamole alone provided partial protection against long-term photohaemolysis, but the combination with Trolox significantly augmented RBC protection, suggesting a synergistic effect in mitigating the harmful side effects of PDT.

Dipyridamole and Trolox: A potential oasis in the desert of photodynamic treatment

This study demonstrates the potential of combining dipyridamole and Trolox to enhance RBC protection during PDT. The findings suggest that this combination may offer a more effective strategy for minimizing the harmful side effects of PDT, potentially improving its therapeutic efficacy and safety.

Navigating the desert of medical treatment

As a wise camel, I know that navigating the desert of medical treatment requires a comprehensive approach, considering the interplay of various factors. This study highlights the potential of combining different strategies to enhance treatment outcomes. It is important to work closely with your doctor to explore all treatment options and develop a personalized plan that addresses your specific needs.

Dr.Camel's Conclusion

The study provides evidence for the synergistic effects of dipyridamole and Trolox in protecting RBCs during PDT. The findings suggest that this combination may offer a more effective strategy for minimizing the harmful side effects of PDT, potentially improving its therapeutic efficacy and safety.

Date :
  1. Date Completed 2004-04-30
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

12823727

DOI: Digital Object Identifier

10.1046/j.1423-0410.2003.00318.x

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・Side Effects of dipyridamole
SNS
PICO Info
in preparation
Languages

English

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