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Methimazole-induced damage in the olfactory mucosa: effects on ultrastructure and glutathione levels.

Author: BergströmUlrika, BritteboEva B, GiovanettiAnna, PirasElena

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Methimazole is an antithyroid drug that can cause loss of smell and taste. This study examined the role of glutathione in methimazole-induced damage to the olfactory mucosa in mice. Methimazole reduced glutathione levels in the olfactory mucosa and caused damage to the olfactory epithelium, suggesting that glutathione plays a role in methimazole-induced olfactory toxicity.
Paper Details　
Original Abstract of the Article :
Methimazole is an antithyroid drug that can induce loss of smell and taste in humans. It is also an olfactory toxicant in rodents. The aim of the present study was to examine involvement of glutathione in methimazole-induced damage of the olfactory mucosa (OM) of mice, and to study early onset of th...See full text at original site
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引用元：
https://doi.org/10.1080/01926230390201101

データ提供：米国国立医学図書館（NLM）

Methimazole: Exploring the Impact on Olfactory Mucosa and Glutathione Levels

This study investigates the impact of methimazole, an antithyroid drug, on the olfactory mucosa (OM) of mice. The researchers examined the role of glutathione in methimazole-induced damage to the OM, analyzing changes in glutathione levels and observing structural alterations using transmission electron microscopy (TEM). This study provides valuable insights into the potential olfactory toxicity associated with methimazole treatment.

The Importance of Understanding Drug-Induced Olfactory Toxicity

This research underscores the importance of understanding the potential side effects of medications, particularly those that may impact sensory functions. The study's findings highlight the potential of methimazole to induce damage to the OM, emphasizing the need for careful monitoring and awareness of this potential adverse effect. This research contributes to the growing body of knowledge on drug-induced olfactory toxicity.

The Interplay of Glutathione and Olfactory Function: A Crucial Link

The study's focus on glutathione and its role in methimazole-induced damage to the OM highlights the intricate interplay of biochemical pathways and sensory function. The researchers' observations provide valuable insights into the molecular mechanisms underlying olfactory toxicity. This study underscores the importance of understanding these interconnected processes to develop safer and more effective treatments.

Dr.Camel's Conclusion

This research is a reminder that even seemingly innocuous substances can have unforeseen effects. The study's exploration of methimazole's impact on the olfactory mucosa highlights the importance of understanding the intricate connections between our internal environment and our senses. Just as a camel relies on its sense of smell to navigate the desert, we must carefully consider the potential consequences of medications on our olfactory functions.

Date :
  1. Date Completed 2004-03-10
  2. Date Revised 2017-02-14
Further Info :

Pubmed ID

12851103

DOI: Digital Object Identifier

10.1080/01926230390201101

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PICO Info
in preparation
Languages

English

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