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Molecular effects of volume expansion on the renal sodium phosphate cotransporter.

Author: DeiningerPrescott, Ianosi-IrimieMonica, PuschettJules B, RabonEdd, RobinsonJames, VuHop V, WhitbredJoy

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the phosphorylation of a 72 kDa protein in the proximal tubular brush border membrane of rats subjected to volume expansion. The results showed a significant increase in the phosphorylation of this protein in rats undergoing volume expansion.
Paper Details　
Original Abstract of the Article :
Volume Expansion (VE) results in both natriuresis and a phosphaturia. In previous studies, Sprague-Dawley rats were infused with a modified saline solution. The expansion procedure resulted in a 70% increase in the phosphorylation of a 72 kDa proximal tubular brush border membrane (BBM) protein. In ...See full text at original site
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引用元：
https://doi.org/10.1097/00000441-200307000-00001

データ提供：米国国立医学図書館（NLM）

Exploring the Desert of Renal Function: The Impact of Volume Expansion

This research investigates the molecular effects of volume expansion (VE) on the renal sodium phosphate cotransporter, a critical component of kidney function. The authors studied the impact of VE on the phosphorylation of a 72 kDa proximal tubular brush border membrane (BBM) protein in Sprague-Dawley rats. The findings provide insights into the mechanisms by which VE regulates renal function.

Volume Expansion: A Journey Through the Kidney's Desert

The study revealed a significant increase in the phosphorylation of the 72 kDa BBM protein in response to VE. These findings shed light on the molecular mechanisms underlying the natriuresis and phosphaturia observed during VE.

Understanding the Kidney's Desert: A Key to Health

This research contributes to our understanding of renal function and the impact of volume expansion on kidney physiology. Understanding these mechanisms is crucial for developing effective treatments for kidney disorders and for maintaining overall health.

Dr. Camel's Conclusion

This research is like a camel trek through a desert, revealing the intricate workings of the kidneys. By studying the impact of volume expansion on the renal sodium phosphate cotransporter, we gain valuable insights into the complex mechanisms that regulate kidney function.

Date :
  1. Date Completed 2003-08-20
  2. Date Revised 2019-07-17
Further Info :

Pubmed ID

12861119

DOI: Digital Object Identifier

10.1097/00000441-200307000-00001

Related Literature

Article Analysis
・Effects of sodium phosphate
SNS
PICO Info
in preparation
Languages

English

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