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Effects of aprepitant on the pharmacokinetics of ondansetron and granisetron in healthy subjects.

Author: BlumRobert A, BusilloJohn, GoldbergMichael R, GottesdienerKevin M, GreenbergHoward E, HesneyMichael, HustadCarolyn M, KraftWalter K, LatesChristian, MajumdarAnup, McCreaJacqueline, MurphyM Gail, OrlowskiLaura H, PanebiancoDeborah, PettyKevin J, Van BurenSandi, WaldmanScott A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Aprepitant does not significantly alter the pharmacokinetic profiles of ondansetron or granisetron, two commonly used antiemetics for chemotherapy-induced nausea and vomiting (CINV).
Paper Details　
Original Abstract of the Article :
BACKGROUND: The neurokinin-1-receptor antagonist aprepitant, when given in combination with a corticosteroid and a 5-hydroxytryptamine type 3 (5-HT(3))-receptor antagonist, has been shown to be effective for the prevention of acute and delated chemotherapy-induced nausea and vomiting (CINV). OBJECT...See full text at original site
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引用元：
https://doi.org/10.1016/s0149-2918(03)80128-5

データ提供：米国国立医学図書館（NLM）

Aprepitant and Antiemetics: A Journey Through the Desert of Nausea

Chemotherapy-induced nausea and vomiting (CINV) can be a debilitating side effect of cancer treatment, significantly impacting patients' quality of life. Aprepitant, a neurokinin-1-receptor antagonist, has emerged as a powerful tool for preventing both acute and delayed CINV. This study investigated the potential interactions between aprepitant and two commonly used 5-HT(3)-receptor antagonists, ondansetron and granisetron, commonly used to treat CINV.

The study found that coadministration of aprepitant had no clinically significant effect on the pharmacokinetic profiles of either ondansetron or granisetron in healthy subjects. This reassuring finding suggests that aprepitant can be safely combined with these commonly used antiemetics, potentially enhancing its effectiveness in preventing CINV.

Navigating the Desert of Nausea: A Safer Path

Chemotherapy-induced nausea and vomiting (CINV) is a harsh and challenging desert for cancer patients. This study offers a glimmer of hope, demonstrating that aprepitant can be safely combined with other commonly used antiemetics, potentially offering a smoother and more effective path to managing this debilitating side effect of cancer treatment.

A New Oasis in the Desert of Nausea: Aprepitant and Antiemetics

Aprepitant, a new weapon in the fight against CINV, offers a potential oasis for patients struggling with this debilitating side effect of cancer treatment. This study provides reassurance that aprepitant can be safely combined with other antiemetics, potentially enhancing its effectiveness and improving the overall treatment experience.

Dr.Camel's Conclusion

Aprepitant, like a resourceful camel navigating a harsh desert, provides relief from the debilitating effects of CINV. This study demonstrates that aprepitant can be safely combined with other antiemetics, offering a more effective and potentially smoother journey for cancer patients facing this challenge.

Date :
  1. Date Completed 2003-09-09
  2. Date Revised 2019-09-22
Further Info :

Pubmed ID

12867217

DOI: Digital Object Identifier

10.1016/s0149-2918(03)80128-5

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Article Analysis
・Effects of aprepitant
SNS
PICO Info
in preparation
Languages

English

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