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[Inhibition by CTLA-4Ig on herpetic stromal keratitis in a murine model].

Author: ShuHong, XiaLi-kun, ZhangJin-song

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Blockade of B7:CD28/CTLA-4 costimulation by CTLA-4Ig inhibited the proliferation of T cells and Th1 response, impairing the onset and severity of herpetic stromal keratitis.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To investigate the inhibition by CTLA-4Ig on herpetic stromal keratitis (HSK). METHODS: BALB/c mice infected with HSV-1 Mckrae strain by corneal scarification were injected intraperitoneally with murine CTLA-4Ig given on days 0, +2, +4 after the infection. The effects of CTLA-4Ig on HSK ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12880576

データ提供：米国国立医学図書館（NLM）

Fighting Herpes Keratitis: A New Immunotherapy Approach

This study explores the potential of a novel immunotherapy approach, CTLA-4Ig, to combat herpetic stromal keratitis (HSK), a serious eye infection caused by the herpes simplex virus (HSV). The researchers tested the effects of CTLA-4Ig in a mouse model of HSK. They found that CTLA-4Ig significantly reduced the severity of HSK by inhibiting the immune response to HSV. This approach targeted the CD28/CTLA-4 pathway, which plays a crucial role in regulating immune responses.

A Promising Approach to Herpes Keratitis

This study presents a promising new approach to treating HSK using immunotherapy. The researchers demonstrated that CTLA-4Ig can effectively suppress the immune response to HSV, reducing the severity of HSK. This approach could be particularly beneficial for patients who are not responding well to conventional treatments.

Understanding Herpes Keratitis

This study highlights the importance of understanding the immune system's role in combating viral infections like HSK. It also underscores the potential of immunotherapy to treat these infections.

Dr.Camel's Conclusion

This study explores the potential of a novel immunotherapy approach, CTLA-4Ig, to combat herpetic stromal keratitis (HSK), a serious eye infection caused by the herpes simplex virus (HSV). The researchers tested the effects of CTLA-4Ig in a mouse model of HSK. They found that CTLA-4Ig significantly reduced the severity of HSK by inhibiting the immune response to HSV. This approach targeted the CD28/CTLA-4 pathway, which plays a crucial role in regulating immune responses. This study presents a promising new approach to treating HSK using immunotherapy. The researchers demonstrated that CTLA-4Ig can effectively suppress the immune response to HSV, reducing the severity of HSK. This approach could be particularly beneficial for patients who are not responding well to conventional treatments.

Date :
  1. Date Completed 2006-02-07
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

12880576

DOI: Digital Object Identifier

12880576

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