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Luteal phase dose-response relationships of the antiprogestin CDB-2914 in normally cycling women.

Author: BlyeRichard, FiggWilliam D, MullenNancy, NiemanLynnette K, PassaroMaureen D, PiquionJohann, SutherlandDorette, ZhaiSuoping

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

The synthetic steroid CDB-2914 binds to progesterone and glucocorticoid receptors and has antiprogestational activity in animals at doses 50-fold less than those required for antiglucocorticoid effects. This suggests potential therapeutic use in progesterone-dependent conditions such as endometriosis and fibroids.
Paper Details　
Original Abstract of the Article :
Progesterone receptor modulators have potential therapeutic use in progesterone-dependent conditions such as endometriosis, fibroids and induction of labour. The synthetic steroid CDB-2914 binds to the progesterone and glucocorticoid receptors. In animals it has antiprogestational activity at doses ...See full text at original site
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引用元：
https://doi.org/10.1093/humrep/deg342

データ提供：米国国立医学図書館（NLM）

CDB-2914: A Potential Oasis in the Desert of Progesterone-Dependent Conditions

The world of reproductive health is a vast and intricate desert, with various conditions like endometriosis and fibroids posing challenges for women's well-being. This research explores CDB-2914, a synthetic steroid with potential therapeutic applications in managing these conditions. The study delves into the dose-response relationships of CDB-2914, investigating its antiprogestational effects in normally cycling women.

CDB-2914: A Promising Tool for Hormonal Balance

The findings suggest that CDB-2914 exhibits antiprogestational activity at remarkably low doses, making it a potentially powerful tool for managing progesterone-dependent conditions. This is akin to finding a small, but potent spring of water in the desert that can sustain life.

Potential Benefits and Future Exploration: Navigating the Desert of Reproductive Health

CDB-2914 holds promise for alleviating the suffering of women with conditions like endometriosis and fibroids, offering potential relief from their symptoms. However, further research is needed to fully understand its effects and ensure its safe and effective use. This research is a valuable step in the ongoing quest to navigate the complex landscape of reproductive health.

Dr.Camel's Conclusion

This research offers a glimmer of hope in the desert of progesterone-dependent conditions. CDB-2914, with its potent antiprogestational effects, could potentially become a valuable tool in managing these conditions. However, as with any new oasis, careful exploration and understanding are crucial to maximizing its benefits.
Date :
  1. Date Completed 2004-04-21
  2. Date Revised 2019-05-13
Further Info :

Pubmed ID

12923133

DOI: Digital Object Identifier

10.1093/humrep/deg342

Related Literature

Article Analysis
・Effects of progesterone
SNS
PICO Info
in preparation
Languages

English

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