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Altered diurnal rhythm of intestinal peptide transporter by fasting and its effects on the pharmacokinetics of ceftibuten.

Author: InuiKen-ichi, OkudaMasahiro, PanXiaoyue, TeradaTomohiro

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that fasting disrupts the diurnal rhythm of intestinal PEPT1, a transporter protein involved in the absorption of peptide-like drugs. The results suggest that the pharmacokinetics of such drugs may be affected by food intake.
Paper Details　
Original Abstract of the Article :
We previously demonstrated that H+/peptide cotransporter PEPT1 shows a diurnal rhythm in the rat small intestine. In the present study, we examined the effect of food intake on the diurnal rhythm of intestinal PEPT1 using fed and fasted rats and also determined whether such variation affected the ph...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12970381

データ提供：米国国立医学図書館（NLM）

Investigating the Diurnal Rhythm of Intestinal Peptide Transporter: The Impact of Fasting

The human body, like a complex desert ecosystem, is governed by intricate rhythms. This study explores the diurnal rhythm of intestinal peptide transporter (PEPT1), a crucial component of nutrient absorption. Researchers investigated the effect of fasting on PEPT1 activity, using fed and fasted rats. The study found that fasting disrupted the diurnal rhythm of PEPT1, suggesting its importance in regulating drug pharmacokinetics. These findings highlight the potential implications of fasting for drug absorption and metabolism.

Fasting and Its Impact on Intestinal Peptide Transport

This research reveals the fascinating interplay between fasting and intestinal peptide transport. Fasting, like a changing desert landscape, can significantly impact the activity of PEPT1. The study emphasizes the importance of considering the timing of drug administration and the potential impact of fasting on drug absorption and metabolism.

Implications for Drug Development and Administration

This research provides valuable insights into the dynamics of intestinal peptide transport and its sensitivity to factors like fasting. These findings are like a compass guiding drug developers and clinicians in optimizing drug administration strategies. The study highlights the importance of personalized drug regimens, taking into account individual factors like fasting and meal patterns.

Dr.Camel's Conclusion

This study delves into the intricate rhythms of intestinal peptide transport, revealing the impact of fasting on PEPT1 activity. It’s like exploring the shifting sands of a desert, discovering how environmental factors can influence biological processes. These findings are crucial for understanding drug absorption and metabolism, and for developing personalized drug regimens that optimize therapeutic outcomes.

Date :
  1. Date Completed 2003-12-10
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

12970381

DOI: Digital Object Identifier

jpet.103.055939

Related Literature

Article Analysis
・Effects of ceftibuten
SNS
PICO Info
in preparation
Languages

English

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