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Effects of tizanidine on morphine physical dependence: attenuation and intensification.

Author: AriciŏgluF, DizdarY, EsinY, KoyuncuŏgluH, UresinY

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Subchronic administration of tizanidine, an alpha2-adrenoceptor agonist, intensified morphine withdrawal syndrome in rats, while acute administration attenuated it. This suggests that tizanidine's effects on morphine dependence are complex and influenced by the duration of treatment.
Paper Details　
Original Abstract of the Article :
It has previously been shown that subchronic and acute administration of L-asparaginase and glutaminase inhibitors D-Aspartic acid (D-ASP) and prolyl-leucyl-glycinamide (PLG) intensifies and attenuates morphine (M) physical dependence, respectively, by the inhibition of ASP and glutamic acid (GLU) p...See full text at original site
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引用元：
https://doi.org/10.1016/0091-3057(92)90016-9

データ提供：米国国立医学図書館（NLM）

Effects of Tizanidine on Morphine Physical Dependence

This study investigates the effects of tizanidine, an alpha 2-adrenoceptor agonist, on morphine physical dependence in rats. The authors examined the impact of tizanidine administration during the development of morphine dependence and during naloxone-induced withdrawal syndrome.

Tizanidine's Dual Effects on Morphine Dependence

The study found that tizanidine can have both intensifying and attenuating effects on morphine physical dependence. Subchronic administration intensified withdrawal symptoms, while acute administration attenuated them. These findings suggest that tizanidine's effects on morphine dependence are complex and depend on the timing and duration of administration.

Understanding Morphine Dependence

This research provides valuable insights into the complex mechanisms underlying morphine physical dependence. It highlights the potential role of alpha 2-adrenoceptors and the interplay of various neurotransmitters in the development and expression of morphine dependence.

Dr. Camel's Conclusion

Morphine dependence, like a mirage in the desert, can be a challenging condition to manage. This study explores the multifaceted effects of tizanidine on morphine dependence. It's a reminder that understanding the complex interactions within the brain is crucial for developing effective treatments for addiction and withdrawal.

Date :
  1. Date Completed 1992-09-25
  2. Date Revised 2019-07-12
Further Info :

Pubmed ID

1355295

DOI: Digital Object Identifier

10.1016/0091-3057(92)90016-9

Related Literature

Article Analysis
・Effects of tizanidine
SNS
PICO Info
in preparation
Languages

English

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