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Inhibition of human liver steroid sulfotransferase activities by drugs: a novel mechanism of drug toxicity?

Author: BamforthK J, CoughtrieM W, DalglieshK

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the inhibitory effects of various drugs on steroid and phenol sulfotransferase activities in human liver cytosol. Several drugs were found to strongly inhibit these activities, with potential implications for understanding adverse drug reactions.
Paper Details　
Original Abstract of the Article :
The inhibition of steroid and phenol sulfotransferase activities in human liver cytosol by a wide range of commonly used drugs was studied. Dehydroepiandrosterone (DHEA) and estrone sulfotransferase activities were strongly inhibited by a number of compounds, with IC50 values ranging between 440 pM ...See full text at original site
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引用元：
https://doi.org/10.1016/0926-6917(92)90006-x

データ提供：米国国立医学図書館（NLM）

Drug Interactions: A Desert of Unforeseen Consequences

This research explores the potential for drug interactions to inhibit steroid sulfotransferase activities in the liver. It's like a desert explorer discovering that certain desert plants can interfere with the body's natural detoxification process. The study highlights the potential for adverse side effects, particularly sexual dysfunction and hormonal imbalances, when certain drugs are combined. It's like a desert mirage that can be both alluring and dangerous.

Drug Interactions: A Complex and Often Overlooked Desert

The study underscores the importance of understanding drug interactions and their potential consequences. It's like navigating a vast and often unexplored desert, where even seemingly innocuous combinations can lead to unexpected results.

Navigating the Desert of Medications: A Journey with Informed Choices

This research emphasizes the importance of consulting with a healthcare professional before combining any medications. It's like a desert expedition, where careful planning and expert guidance are essential for a safe and successful journey.

Dr.Camel's Conclusion

This research reminds us that the desert of drug interactions can be both vast and treacherous. It's important to be aware of potential interactions and to discuss any concerns with your healthcare provider. Remember, informed choices are essential for navigating the complex landscape of medications.

Date :
  1. Date Completed 1992-11-04
  2. Date Revised 2019-06-24
Further Info :

Pubmed ID

1397064

DOI: Digital Object Identifier

10.1016/0926-6917(92)90006-x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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