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Interaction of bovine serum albumin with the surface of a microcrystalline aluminum oxide hydroxide compound: a possible new type of phosphate adsorbent.
Author: HashimuraY, IkawaA, KawadaJ, NishidaM, OoiK, OokuboA, SuzukiT, TomitaY, YoshimuraY
Original Abstract of the Article :
Aluminum hydroxide gel (ALG) has been effective for ameliorating acidosis associated with phosphatemia caused by hemodialysis. However, aluminum accumulation in the body causes severe side effects. As substitute for ALG, a new type of aluminum oxide hydroxide (tentatively named PT-A) was prepared wi...See full text at original site
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引用元:
https://doi.org/10.1002/jps.2600810822
データ提供:米国国立医学図書館(NLM)
A Novel Phosphate Adsorbent: Aluminum Oxide Hydroxide (PT-A)
The [Management of hyperphosphatemia] is a critical aspect of [Hemodialysis]. This research explores the [Potential] of a [New type of aluminum oxide hydroxide (PT-A)] as a [Phosphate adsorbent]. This study aimed to investigate the [Interaction of PT-A with bovine serum albumin (BSA)] and its [Phosphate-binding efficacy]. The authors found that [PT-A] demonstrated [High phosphate-binding efficacy] and [Limited interaction with BSA]. This study suggests that [PT-A] could be a [Promising alternative] to [Aluminum hydroxide gel (ALG)] for [Managing hyperphosphatemia].
Exploring New Sands: A Novel Phosphate Adsorbent for Hemodialysis
This study ventures into the [Desert of renal medicine] with the discovery of a [New and potentially safer phosphate adsorbent]. The [Findings] suggest that [PT-A] could be a [Valuable tool] for [Managing hyperphosphatemia] in [Hemodialysis patients]. The [Limited interaction with BSA] is particularly promising, as it could [Reduce the risk] of [Aluminum accumulation] associated with [Traditional aluminum hydroxide gel (ALG)].
Navigating the Desert of Dialysis: A Safer Alternative
This research offers a [New path] through the [Desert of dialysis]. The [Development of PT-A] could lead to a [Safer and more effective] treatment for [Hyperphosphatemia] in [Hemodialysis patients]. It reminds us that [Innovation] is essential in [Improving patient care] and [Finding solutions] to [Challenging medical conditions].
Dr.Camel's Conclusion
This research introduces a novel aluminum oxide hydroxide compound (PT-A) as a potential alternative to aluminum hydroxide gel for managing hyperphosphatemia in hemodialysis patients. The study's findings demonstrate the promising phosphate-binding efficacy of PT-A with limited interaction with bovine serum albumin, suggesting a potentially safer treatment option for patients undergoing dialysis.
Date :
- Date Completed 1992-11-06
- Date Revised 2019-07-10
Further Info :
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