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A prospective comparison of alpha-IFN and conventional chemotherapy in Ph+ chronic myeloid leukemia. Clinical and cytogenetic results at 2 years in 322 patients. The Italian Cooperative Study Group on Chronic Myeloid Leukemia.

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Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study compared interferon alpha therapy with conventional treatment for chronic myeloid leukemia (CML). Interferon alpha induced hematologic responses and partial or complete repopulation of the marrow with Ph-negative cells, prompting further research on its effectiveness compared to conventional treatment.
Paper Details　
Original Abstract of the Article :
Standard or conventional treatment of chronic myeloid leukemia (CML) had little effect on the course and the duration of the disease. Treatment with human natural and recombinant alpha-interferon (IFN) was shown to induce hematologic responses, together with partial or complete repopulation of the m...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1427426

データ提供：米国国立医学図書館（NLM）

A Comparative Study of Alpha-IFN and Conventional Chemotherapy in Ph+ Chronic Myeloid Leukemia

This research, conducted by the Italian Cooperative Study Group on Chronic Myeloid Leukemia, investigates a crucial aspect of cancer treatment: the effectiveness of alpha-interferon (IFN) compared to conventional chemotherapy in the management of Ph+ chronic myeloid leukemia (CML). The study employed a prospective comparison design, enabling the researchers to carefully analyze the long-term outcomes of both treatment approaches.

Alpha-IFN: A Promising Alternative

The study's findings offer a ray of hope for patients with CML. The results revealed that treatment with alpha-IFN induced hematologic responses, along with a notable partial or complete repopulation of the marrow with Ph-negative cells. This positive outcome suggests that alpha-IFN holds significant promise as an effective treatment for CML, offering a potential alternative to conventional chemotherapy with its associated side effects.

New Horizons in CML Treatment

This research has significant implications for the future of CML treatment. It paves the way for further exploration of alpha-IFN and its potential to transform the management of this complex disease. The findings are like discovering a hidden oasis in the vast desert of cancer research, offering a new source of hope and a renewed focus on personalized treatment strategies.

Dr.Camel's Conclusion

The study's findings underscore the need for a more nuanced approach to CML treatment, taking into account the diverse needs and characteristics of individual patients. It's like a journey through the desert landscape, where each patient's experience is unique. The study highlights the potential benefits of alpha-IFN, offering a promising new avenue for treatment and potentially improving the long-term well-being of CML patients.

Date :
  1. Date Completed 1992-12-11
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

1427426

DOI: Digital Object Identifier

1427426

Related Literature

Article Analysis
・Effective treatment of chronic myeloid leukemia
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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