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Calcipotriol versus coal tar: a prospective randomized study in stable plaque psoriasis.

Author: KaurInderjeet, KumarBhushan, SharmaVikas

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

This study compared the efficacy of 0.005% topical calcipotriol ointment with 5% coal tar ointment in patients with stable plaque psoriasis. The study found that calcipotriol ointment produced a faster initial response and had better cosmetic acceptability. However, after 12 weeks of treatment, coal tar ointment had comparable efficacy. There was no statistically significant difference in the relapse rates between the two modalities.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Topical therapies are the first line of treatment for patients with stable plaque psoriasis (SPP) affecting a limited body surface area. Very few trials comparing newer agents, such as 0.005% topical calcipotriol, with conventional modes of therapy, such as coal tar ointment, have been r...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1046/j.1365-4362.2003.01974.x

データ提供：米国国立医学図書館（NLM）

Calcipotriol vs. Coal Tar: A Race Through the Desert of Psoriasis

Psoriasis, a chronic skin condition, can be a challenging desert to navigate. This study pits two common topical treatments, calcipotriol and coal tar, against each other in a race to alleviate the symptoms of stable plaque psoriasis (SPP). The researchers conducted a prospective, randomized, double-blinded study involving 36 patients with SPP. The study compared the efficacy and safety of the two treatments, analyzing the reduction in the severity of erythema, scaling, and induration (ESI score). The results suggest that calcipotriol may offer a faster initial response and improved cosmetic acceptability, while coal tar demonstrates comparable efficacy over the long term.

A Desert of Clinical Findings

The results of this study revealed that calcipotriol, like a refreshing spring in the desert, provided a faster initial reduction in the severity of SPP lesions, leading to marked improvement in 65.7% of patients compared to 45.8% in the coal tar group. However, after 12 weeks of treatment, the difference in clinical response between the two groups was not significant.

A Desert of Choices

Both calcipotriol and coal tar have their own strengths and weaknesses. The decision of which treatment to choose depends on the individual patient's preferences and the severity of their condition. A healthcare professional can provide guidance based on the specific needs of each patient.

Dr.Camel's Conclusion

Navigating the desert of psoriasis requires a strategic approach. This study offers valuable insights into the comparative efficacy of two common topical treatments. The choice between calcipotriol and coal tar is like choosing the best path through a desert landscape, considering the unique challenges and needs of each individual.

Date :
  1. Date Completed 2004-04-13
  2. Date Revised 2019-07-23
Further Info :

Pubmed ID

14521705

DOI: Digital Object Identifier

10.1046/j.1365-4362.2003.01974.x

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・Effective treatment of psoriasis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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