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The effect of human immunodeficiency virus-1 protease inhibitors on the toxicity of a variety of cells.

Author: Colby-GerminarioSusan P, GerminarioRalph J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study assessed the toxicity of HIV-1 protease inhibitors in various cell types. The most toxic protease inhibitor was Saquinavir, while Indinavir was the least toxic. Ritonavir and Amprenavir were more toxic than Indinavir but less toxic than Saquinavir. This study highlights the importance of considering the potential toxicities of protease inhibitors, particularly Saquinavir, when treating HIV-1 infection.
Paper Details　
Original Abstract of the Article :
Protease inhibitors in combination with other antiretroviral drugs have been shown to be efficacious in treating human immunodeficiency virus-1 (HIV-1) infection. The side effects of such a treatment usually involve perturbations of fat metabolism and insulin responsiveness. This has led to a number...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/14561112

データ提供：米国国立医学図書館（NLM）

HIV Protease Inhibitors: Balancing Benefits and Risks

This study delves into the effects of HIV protease inhibitors, a class of medications used to combat HIV infection. Researchers investigated the potential toxicity of these drugs, focusing on their impact on various cell types in the body. This research provides valuable insights into the potential side effects of these medications and their impact on different cell types.

HIV Protease Inhibitors: A Double-Edged Sword

The study revealed that different protease inhibitors have varying levels of toxicity. Saquinavir, for example, was found to be the most toxic, while Indinavir was the least toxic. These findings highlight the importance of considering the specific protease inhibitor and its potential side effects for individual patients.

Managing HIV Treatment: A Balancing Act

This research underscores the need to weigh the benefits of HIV protease inhibitors against their potential risks. Healthcare providers should carefully consider the individual patient's health status and potential side effects when prescribing these medications. For those taking HIV protease inhibitors, it's essential to stay vigilant and communicate any concerns with your healthcare provider.

Dr.Camel's Conclusion

This study is like a desert oasis, offering a glimpse into the intricate world of HIV protease inhibitors. Understanding the potential toxicity of these drugs is crucial for making informed decisions about treatment. It's a reminder that even powerful medications can have unintended consequences, and it's important to weigh those consequences carefully. The journey towards managing HIV is a delicate balance between fighting the virus and safeguarding overall health.

Date :
  1. Date Completed 2004-07-30
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

14561112

DOI: Digital Object Identifier

0309068

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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