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A comparison of the effects of nevirapine and nelfinavir on metabolism and body habitus in antiretroviral-naive human immunodeficiency virus-infected patients: a randomized controlled study.

Author: BarberaMaria J, FerrerElena, FisacCesar, FumeroEmilio, PodzamczerDaniel, VilarasauConcepcio, VirgiliNuria

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Nelfinavir (NFV), a protease inhibitor, was compared to nevirapine (NVP), a nonnucleoside reverse transcriptase inhibitor, in HIV-infected patients. NVP offered benefits regarding lipid status, with enhanced HDL-c concentrations and decreased TC/HDL-c ratios. The inclusion of NVP should be considered for patients at high coronary risk.
Paper Details　
Original Abstract of the Article :
New HIV therapies have significantly increased survival, but are associated with multiple metabolic changes, most of them related to the protease inhibitors (PIs). The objective of this study was to elucidate and compare morphological and metabolic alterations in HIV-infected antiretroviral-naive pa...See full text at original site
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引用元：
https://doi.org/10.1210/jc.2002-021830

データ提供：米国国立医学図書館（NLM）

Navigating the Metabolic Landscape: Comparing Nelfinavir and Nevirapine in HIV Treatment

HIV infection, a complex and challenging condition, requires long-term treatment with antiretroviral medications. This study, like a camel traversing a vast and unforgiving desert, explores the metabolic effects of two different antiretroviral regimens: nelfinavir (NFV) and nevirapine (NVP), in antiretroviral-naive HIV-infected patients.

A Tale of Two Regimens: Metabolic Effects of Nelfinavir and Nevirapine

The researchers compared the morphological and metabolic alterations in patients receiving either NFV or NVP in combination with two nucleoside reverse transcriptase inhibitors. The findings, like a series of oases in a vast desert, reveal distinct metabolic effects of the two regimens. NVP was associated with a more favorable lipid profile, including increased HDL-c levels, while NFV did not significantly alter the TC/HDL-c ratio, suggesting a lower cardiovascular risk.

Optimizing HIV Treatment: Balancing Efficacy and Metabolic Effects

This study, like a skilled desert navigator, underscores the importance of considering metabolic effects when choosing HIV treatment regimens. The findings highlight the potential benefits of NVP in terms of lipid status and cardiovascular risk. The study emphasizes the need for individualized treatment approaches, taking into account patient-specific factors, such as cardiovascular risk, to optimize treatment outcomes.

Dr.Camel's Conclusion

This study provides valuable insights into the metabolic effects of different antiretroviral regimens for HIV infection. The findings highlight the importance of considering individual patient factors, such as cardiovascular risk, when choosing treatment options. The research underscores the need for ongoing research to optimize HIV treatment strategies and minimize the long-term metabolic complications of antiretroviral therapy.

Date :
  1. Date Completed 2003-12-09
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

14602748

DOI: Digital Object Identifier

10.1210/jc.2002-021830

Related Literature

Article Analysis
・Effects of nevirapine
SNS
PICO Info
in preparation
Languages

English

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