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Administration of progesterone produces mild sedative-like effects in men and women.

Author: HaugerRichard, LindseySommer, PurdyRobert H, SöderpalmAnna H V, Witde Harriet

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Progesterone was investigated for its effects on mood, subjective feelings, and psychomotor performance in both men and women. A single dose of progesterone produced small, delayed increases in heart rate and feelings of fatigue. It also impaired smooth eye pursuit. These effects were modest and not directly related to plasma concentrations. Overall, the study suggests that progesterone and its metabolites can have sedative-like effects in both sexes.
Paper Details　
Original Abstract of the Article :
The goal of this study was to investigate the behavioral and subjective effects of a single dose of progesterone in men and women. Certain metabolites of progesterone (e.g., allopregnanolone) are potent positive allosteric modulators of GABA(A) receptors, and produce sedative-like effects in laborat...See full text at original site
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引用元：
https://doi.org/10.1016/s0306-4530(03)00033-7

データ提供：米国国立医学図書館（NLM）

Progesterone: Exploring Its Sedative-Like Effects in Men and Women

Progesterone, a female sex hormone, has been traditionally associated with reproductive functions. However, this research explores the potential sedative-like effects of progesterone in both men and women. The study investigated the behavioral and subjective effects of a single dose of progesterone in healthy volunteers, finding that progesterone administration produced small, delayed increases in heart rate, feelings of fatigue, and impaired smooth eye pursuit. The research provides insights into the broader neuroactive properties of progesterone and its potential impact on behavior and cognition.

The Neuroactive Properties of Progesterone

This study provides evidence for the neuroactive properties of progesterone, demonstrating its potential to induce sedative-like effects in both men and women. The research highlights the importance of understanding the broader physiological roles of hormones and their potential influence on behavior and cognition. The authors emphasize the need for further research to explore the mechanisms underlying these effects and their potential clinical significance.

Understanding the Complexities of Hormonal Effects

This research reminds us that hormones, traditionally associated with specific biological functions, can exert wider-ranging effects on the body and mind. The study highlights the importance of considering the complex interplay of hormones and their potential influence on various physiological and behavioral processes. The authors encourage continued research to further elucidate the diverse roles of hormones and their impact on human health and well-being.

Dr. Camel's Conclusion

This research takes us on a fascinating journey through the realm of hormones and their influence on human behavior. Just as a camel adapts to the harsh desert environment, our bodies constantly adapt to the changing landscape of hormones. This study provides evidence that progesterone, beyond its well-known reproductive roles, can exert sedative-like effects. This research underscores the importance of understanding the broader impact of hormones on our physiology and behavior, reminding us that the intricate workings of our bodies hold countless surprises waiting to be discovered.

Date :
  1. Date Completed 2004-05-06
  2. Date Revised 2019-09-17
Further Info :

Pubmed ID

14644065

DOI: Digital Object Identifier

10.1016/s0306-4530(03)00033-7

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・Effects of progesterone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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