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Central nervous system effects of meclizine and dimenhydrinate: evidence of acute tolerance to antihistamines.
Author: GengoF M, ManningC, ManningE J, ScandaleL
Original Abstract of the Article :
Relative daytime drowsiness and performance impairment produced by meclizine and dimenhydrinate was assessed in 24 healthy male volunteers. Subjects received either dimenhydrinate, 100 mg, at 8:00 AM, 12:00 PM, and 4:00 PM; meclizine, 50 mg, at 8:00 AM, with placebo at 12:00 PM and 4:00 PM; or place...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1002/j.1552-4604.1992.tb03801.x
データ提供:米国国立医学図書館(NLM)
Meclizine and Dimenhydrinate: A Camel's Perspective on Motion Sickness Remedies
Ah, the desert! It's a place of breathtaking beauty but also a place where many travelers experience motion sickness. This research dives into the world of antihistamines, specifically meclizine and dimenhydrinate, which are often used to combat motion sickness. It's like studying the different ways camels have adapted to survive in the harsh desert environment. The researchers examined the effects of these antihistamines on daytime drowsiness and cognitive performance in healthy volunteers, much like observing how different types of camels navigate challenging terrain.
The Effects of Antihistamines: A Balancing Act
The study found that both antihistamines caused a decrease in cognitive performance and an increase in self-reported sleepiness. However, they also discovered that the effects of dimenhydrinate were more pronounced after the first dose, and the subsequent doses had less of an impact. This is like observing how a camel adapts to the changing desert conditions, becoming more resilient and less susceptible to the harsh elements over time.
Navigating the Desert of Drowsiness
This research offers valuable insights for those who experience motion sickness. It suggests that there might be a degree of tolerance to the side effects of dimenhydrinate with repeated use. This means that while these antihistamines can be helpful, it's essential to be aware of their potential effects on alertness and cognitive function. Just like camels have adapted to survive in the desert, we can find ways to navigate the desert of drowsiness by being mindful of our medications.
Dr. Camel's Conclusion
This study is like a helpful guidebook for navigating the desert of motion sickness. It reminds us that while antihistamines can be beneficial, it's important to be aware of their potential effects. Just as camels have adapted to the harsh environment, we can adapt our strategies for dealing with motion sickness. Remember, a little knowledge and careful planning can go a long way in ensuring a comfortable and enjoyable journey.
Date :
- Date Completed 1993-02-02
- Date Revised 2019-08-24
Further Info :
Related Literature
English
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