Central nervous system effects of meclizine and dimenhydrinate: evidence of acute tolerance to antihistamines.

Author: GengoF M, ManningC, ManningE J, ScandaleL

Paper Details 
Original Abstract of the Article :
Relative daytime drowsiness and performance impairment produced by meclizine and dimenhydrinate was assessed in 24 healthy male volunteers. Subjects received either dimenhydrinate, 100 mg, at 8:00 AM, 12:00 PM, and 4:00 PM; meclizine, 50 mg, at 8:00 AM, with placebo at 12:00 PM and 4:00 PM; or place...See full text at original site
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引用元:
https://doi.org/10.1002/j.1552-4604.1992.tb03801.x

データ提供:米国国立医学図書館(NLM)

Meclizine and Dimenhydrinate: A Camel's Perspective on Motion Sickness Remedies

Ah, the desert! It's a place of breathtaking beauty but also a place where many travelers experience motion sickness. This research dives into the world of antihistamines, specifically meclizine and dimenhydrinate, which are often used to combat motion sickness. It's like studying the different ways camels have adapted to survive in the harsh desert environment. The researchers examined the effects of these antihistamines on daytime drowsiness and cognitive performance in healthy volunteers, much like observing how different types of camels navigate challenging terrain.

The Effects of Antihistamines: A Balancing Act

The study found that both antihistamines caused a decrease in cognitive performance and an increase in self-reported sleepiness. However, they also discovered that the effects of dimenhydrinate were more pronounced after the first dose, and the subsequent doses had less of an impact. This is like observing how a camel adapts to the changing desert conditions, becoming more resilient and less susceptible to the harsh elements over time.

Navigating the Desert of Drowsiness

This research offers valuable insights for those who experience motion sickness. It suggests that there might be a degree of tolerance to the side effects of dimenhydrinate with repeated use. This means that while these antihistamines can be helpful, it's essential to be aware of their potential effects on alertness and cognitive function. Just like camels have adapted to survive in the desert, we can find ways to navigate the desert of drowsiness by being mindful of our medications.

Dr. Camel's Conclusion

This study is like a helpful guidebook for navigating the desert of motion sickness. It reminds us that while antihistamines can be beneficial, it's important to be aware of their potential effects. Just as camels have adapted to the harsh environment, we can adapt our strategies for dealing with motion sickness. Remember, a little knowledge and careful planning can go a long way in ensuring a comfortable and enjoyable journey.

Date :
  1. Date Completed 1993-02-02
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

1474173

DOI: Digital Object Identifier

10.1002/j.1552-4604.1992.tb03801.x

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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