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The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity.

Author: Ang-LeeMichael K, AungHan H, MehendaleSangeeta, XiaoYingping, XieJing-Tian, YuanChun-Su

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Valerian extract and its constituent valerenic acid have GABAergic effects on brainstem neuronal activity, potentially potentiating the sedative effects of anesthetics and other medications that act on GABA receptors.
Paper Details　
Original Abstract of the Article :
Valerian is a medicinal herb that produces anxiolytic and sedative effects. It was suggested that valerian acts via gamma-aminobutyric acid (GABA)ergic mechanisms. Previous studies showed binding of valerian extract to GABA receptors, but the functional effect of the binding has not been demonstrate...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/14742369

データ提供：米国国立医学図書館（NLM）

The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity

The world of [neuropharmacology] is a labyrinthine desert, filled with complex pathways and intricate mechanisms. This study delves into the [GABAergic effects] of valerian, a medicinal herb known for its anxiolytic and sedative properties.

Exploring the GABAergic Pathway

The researchers used an [in vitro neonatal rat brainstem preparation] to investigate the effects of valerian extract and valerenic acid, one of its major constituents, on neuronal activity. The study found that both valerian extract and valerenic acid inhibited neuronal firing in a [GABA(A) receptor-dependent manner], suggesting that these compounds act by modulating GABAergic activity.

Potential Interactions

The study highlights the potential for [interactions between valerian and other medications], particularly those that act on GABA receptors. This knowledge is crucial for clinicians to ensure the safe and effective use of valerian, especially in situations where it might be co-administered with other medications.

Dr. Camel's Conclusion

This study provides valuable insights into the [GABAergic mechanisms] underlying the anxiolytic and sedative effects of valerian. The researchers' careful investigation of these effects, using an in vitro rat brainstem preparation, offers a glimpse into the complex interactions between valerian and the nervous system. This knowledge is essential for understanding the potential benefits and risks of valerian use, especially in the context of other medications. As Dr. Camel, I am always intrigued by the complexities of the nervous system and the potential of natural remedies like valerian to offer therapeutic benefits. It is important to approach the use of such remedies with caution and awareness of potential interactions.
Date :
  1. Date Completed 2004-02-19
  2. Date Revised 2021-09-02
Further Info :

Pubmed ID

14742369

DOI: Digital Object Identifier

00000539-200402000-00016

Related Literature

Article Analysis
・Effective treatment of valerian
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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