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Synthesis and pharmacological evaluation of some phenothiazines as antidepressants.
Author: KhannaR, PalitG, ShankerK, SinghV, SrivastavaV K
Original Abstract of the Article :
10-Hydrazino acetyl phenothiazine (II) has been converted to N-10-acetyl amino phenothiazine-N-phenyl thiourea (III) which have been converted to 3-aryl-1-(10-phenothiazine acetyl amino)-2,3-dihydro-2-thioxo-4,6-(1H,5H) pyrimidinones (IV) on condensation with aryl amines and aryl aldehydes yielded 3...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/1497683
データ提供:米国国立医学図書館(NLM)
Phenothiazines: Exploring New Antidepressant Potential
The search for effective and safe antidepressants continues to be a crucial endeavor in the field of mental health. This study investigates the potential antidepressant activity of various phenothiazine derivatives, exploring their therapeutic potential and comparing their efficacy to existing tricyclic antidepressants. It's like a camel traversing a vast desert of chemical compounds, seeking to uncover new and potent therapeutic agents for combating mental illness.
Phenothiazine Derivatives: Potential Antidepressant Activity
The study found that several phenothiazine derivatives exhibited significant antidepressant activity in experimental models, surpassing the efficacy of imipramine, a widely used tricyclic antidepressant. These findings suggest that phenothiazines may offer a promising alternative for treating depression, potentially providing a new avenue for developing effective and well-tolerated medications.
New Horizons in Antidepressant Research
This study highlights the importance of exploring new and innovative approaches to treating depression. It's like discovering a new oasis in a desert of conventional therapies, offering hope and a path toward developing more effective and safe medications for those struggling with mental illness. This research encourages continued exploration and innovation in the search for new and improved antidepressants.
Dr.Camel's Conclusion
This research offers a promising glimpse into the future of antidepressant treatment. It's like finding a hidden treasure trove of therapeutic potential in the vast desert of chemical compounds. This study encourages continued exploration and innovation, seeking to provide a brighter future for those grappling with mental illness.
Date :
- Date Completed 1992-09-10
- Date Revised 2013-11-21
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English
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