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Effects of aluminum hydroxide and calcium carbonate antacids on the bioavailability of ciprofloxacin.

Author: FrostR W, LasseterK C, LettieriJ T, NoeA J, ShamblenE C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Aluminum hydroxide antacid significantly reduced the bioavailability of ciprofloxacin, while calcium carbonate antacid reduced it to a lesser extent. Therefore, antacids containing either aluminum or calcium should not be administered with ciprofloxacin.
Paper Details　
Original Abstract of the Article :
This study was designed to determine the effects of an aluminum hydroxide antacid and a calcium carbonate antacid on the bioavailability of ciprofloxacin (Cipro). Cipro (750 mg) was administered orally to 12 healthy volunteers in a three-way randomized crossover design. The three treatments included...See full text at original site
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引用元：
https://doi.org/10.1128/AAC.36.4.830

データ提供：米国国立医学図書館（NLM）

Antacids and Ciprofloxacin: A Cautionary Tale

Ciprofloxacin is a commonly used antibiotic, but its absorption can be affected by antacids. This study investigated the effects of aluminum hydroxide and calcium carbonate antacids on the bioavailability of ciprofloxacin in healthy volunteers. The study found that both antacids significantly reduced the bioavailability of ciprofloxacin, with aluminum hydroxide having a more pronounced impact. These findings highlight the importance of avoiding co-administration of antacids containing aluminum or calcium with ciprofloxacin to ensure its effectiveness.

Understanding Drug Interactions

This study underscores the importance of understanding potential drug interactions. It highlights the need for careful consideration when co-administering medications, particularly those known to interact with other drugs.

Staying Informed about Medications

Just as a camel navigates the desert with careful attention to its surroundings, we must be aware of the potential interactions between medications. This study emphasizes the importance of consulting with healthcare professionals and staying informed about potential drug interactions to ensure safe and effective medication use.

Dr. Camel's Conclusion

The study demonstrates that antacids containing aluminum or calcium significantly reduce the bioavailability of ciprofloxacin, highlighting the importance of avoiding their co-administration to ensure the antibiotic's effectiveness.

Date :
  1. Date Completed 1992-09-16
  2. Date Revised 2021-05-26
Further Info :

Pubmed ID

1503446

DOI: Digital Object Identifier

10.1128/AAC.36.4.830

Related Literature

Article Analysis
・Effects of aluminum hydroxide
SNS
PICO Info
in preparation
Languages

English

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