Side effects of azathioprine in patients with Crohn's disease.

Author: GoulletMohammed, NaberTon H J, de JongDirk J

Paper Details 
Original Abstract of the Article :
OBJECTIVE: In clinical trials 0-15% of patients discontinued azathioprine due to side effects. The aim of this study was to assess the rate of side effects leading to discontinuation of azathioprine and to determine predictive factors for discontinuation. DESIGN: A retrospective cohort analysis of ...See full text at original site
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引用元:
https://doi.org/10.1097/00042737-200402000-00014

データ提供:米国国立医学図書館(NLM)

Azathioprine: A Double-Edged Sword in Crohn's Disease Therapy

The field of gastroenterology is constantly seeking new and effective therapies for inflammatory bowel diseases, such as Crohn's disease. This study investigates the side effects of azathioprine, an immunosuppressant drug commonly used to manage Crohn's disease. The researchers analyze data from patients with Crohn's disease who were prescribed azathioprine, examining the rate of adverse events leading to discontinuation of the medication and identifying potential risk factors.

The Balancing Act of Azathioprine: Benefits and Risks

The study reveals a significant rate of adverse events leading to azathioprine discontinuation, highlighting the potential for this medication to cause both benefits and harms. The researchers found that patients who discontinued azathioprine due to adverse events were more likely to have used lower initial doses of prednisone, a corticosteroid drug commonly used to manage Crohn's disease. This suggests that initial prednisone dosing might play a role in mitigating azathioprine-related side effects.

Navigating the Desert of Crohn's Disease Therapy: A Guide for Patients

This study emphasizes the importance of careful monitoring for side effects when taking azathioprine. Patients should discuss potential risks and benefits with their doctors, including potential interactions with other medications. It's also crucial to maintain open communication with your healthcare provider, reporting any new or worsening symptoms.

Dr.Camel's Conclusion

This study provides valuable insights into the side effects of azathioprine in Crohn's disease therapy. It underscores the importance of weighing potential benefits against risks and collaborating with healthcare professionals to optimize treatment outcomes.

Date :
  1. Date Completed 2004-06-10
  2. Date Revised 2019-09-06
Further Info :

Pubmed ID

15075996

DOI: Digital Object Identifier

10.1097/00042737-200402000-00014

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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