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A randomized trial of amifostine and carmustine-containing chemotherapy to assess lung-protective effects.

Author: BlumeKarl G, DanseyRoger, JonesRoy B, KleinJared, MartinezCharles, MatthesSteven, MurphyJames, NietoYago, Stockerl-GoldsteinKeith E

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This randomized, double-blind, placebo-controlled trial assessed the ability of amifostine to protect patients against acute lung injury associated with cyclophosphamide/cisplatin/carmustine (BCNU). The study found that amifostine, in the tested dose and schedule, did not reduce the incidence of acute lung injury.
Paper Details　
Original Abstract of the Article :
We conducted a randomized, double blind, placebo-controlled multi-institutional trial to assess the ability of amifostine to protect patients against acute lung injury associated with cyclophosphamide/cisplatin/carmustine (BCNU) (STAMP I), a BCNU-containing high dose chemotherapy regimen used with h...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15077226

データ提供：米国国立医学図書館（NLM）

Protecting the Lungs: A Quest for Safe Chemotherapy

This study explores the complex world of chemotherapy, particularly focusing on the potential lung toxicity associated with certain medications. It’s like a camel caravan navigating a desert of toxic substances, seeking to protect its precious cargo. The researchers investigated the effectiveness of amifostine, a medication designed to protect the lungs from damage, in reducing lung injury associated with a specific chemotherapy regimen.

Navigating the Desert of Chemotherapy

The study unfortunately found that amifostine, while promising, did not significantly reduce the risk of lung injury in this particular chemotherapy regimen. It’s like discovering that a certain oasis, while seemingly attractive, doesn't offer the expected respite.

Understanding the Risks of Chemotherapy

This study underscores the importance of carefully considering the potential side effects of chemotherapy and working closely with healthcare professionals to minimize risks. It’s like being aware of the dangers that can lurk in the desert and taking precautions to stay safe.

Dr.Camel's Conclusion

This study highlights the challenges associated with developing effective strategies to protect the lungs from the harmful effects of chemotherapy. It's like a reminder that the desert of medical research is full of surprises, and the search for safe and effective treatments is an ongoing journey.

Date :
  1. Date Completed 2004-12-15
  2. Date Revised 2020-12-08
Further Info :

Pubmed ID

15077226

DOI: Digital Object Identifier

S1083879104000461

Related Literature

Article Analysis
・Effects of carmustine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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