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Narrowband UVB and cream psoralen-UVA combination therapy for plaque-type psoriasis.

Author: BoehnckeWolf-Henning, Grundmann-KollmannMarcella, KaufmannRoland, KrutmannJean, LudwigRalf, OchsendorfFalk, PoddaMaurizio, ThaciDiamant, ZollnerThomas M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

PUVA therapy (psoralen plus UVA light) and narrowband UVB light therapy are the main treatments for moderate to severe psoriasis. Topical PUVA therapy has been developed to reduce side effects caused by absorption of psoralen into the body. Topical PUVA therapy has been shown to be effective for psoriasis.
Paper Details　
Original Abstract of the Article :
Psoralen-UVA (PUVA) and narrowband UVB (311-nm) therapy are considered to be first-line phototherapies for patients with moderate to severe psoriasis. To reduce side effects as a result of systemic resorption of psoralens, topical PUVA therapies have been developed and proven to be effective in the ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15097957

データ提供：米国国立医学図書館（NLM）

Shining Light on Psoriasis: Topical PUVA and Narrowband UVB Therapy

Psoriasis, a chronic inflammatory skin condition, can feel like a desert of dryness and discomfort. This research explores the effectiveness of two common phototherapies, psoralen-UVA (PUVA) and narrowband UVB (311-nm), in treating moderate to severe psoriasis. While systemic PUVA therapy has been a mainstay treatment, concerns about potential side effects associated with systemic absorption of psoralens have led to the development of topical PUVA therapies. This study highlights the effectiveness of topical PUVA therapies in managing psoriasis, offering a less invasive approach for patients.

Topical PUVA Therapy: A Targeted Approach to Psoriasis

Topical PUVA therapies, as opposed to systemic treatments, provide a more targeted approach to treating psoriasis. The application of psoralen directly to the affected areas minimizes the risk of systemic absorption, reducing the potential for side effects. The study found that topical PUVA therapies were effective in treating psoriasis, providing a valuable option for patients who are seeking a less invasive treatment method.

Finding Relief from Psoriasis: Balancing Benefits and Risks

While phototherapies like PUVA and narrowband UVB can provide significant relief from psoriasis, it's important to remember that, like a desert landscape, they come with their own set of considerations. Potential side effects, such as sun sensitivity and skin irritation, should be weighed against the benefits of improved skin condition. Regular monitoring and communication with your healthcare provider are crucial for managing psoriasis effectively and safely.

Dr.Camel's Conclusion

Topical PUVA therapy offers a promising alternative to systemic PUVA treatments for psoriasis. By targeting the affected areas, it minimizes systemic absorption and potential side effects. While the journey to manage psoriasis may be long and challenging, finding the right treatment options can help you navigate this desert of discomfort with more ease.

Date :
  1. Date Completed 2004-06-07
  2. Date Revised 2019-07-09
Further Info :

Pubmed ID

15097957

DOI: Digital Object Identifier

S0190962203007928

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Languages

English

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