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Bismuth subsalicylate increases intracellular Ca2+, MAP-kinase activity, and cell proliferation in normal human gastric mucous epithelial cells.
Author: BaconKathy, DeveneyClifford, GilsterJason, MarlinkKatie, RuttenMichael, SheppardBrett
Original Abstract of the Article :
Clinical and laboratory studies have shown that bismuth subsalicylate (BSS) is helpful in the healing of gastric ulcers because of the bactericidal effects of bismuth (Bi3+) on H. pylori. Bismuth or BSS has also been reported to possess other nonbactericidal or "gastroprotective" effects in the stom...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1023/b:ddas.0000020488.55854.99
データ提供:米国国立医学図書館(NLM)
Bismuth Subsalicylate's Role in Gastric Mucous Epithelial Cell Proliferation
Bismuth subsalicylate (BSS), a common remedy for stomach upset, has been known to fight H. pylori bacteria, a major cause of peptic ulcers. But this study delves deeper, exploring BSS's potential to promote gastric mucosal cell growth. Researchers found that BSS increases intracellular calcium levels, activates specific MAP kinases, and stimulates the proliferation of normal human gastric mucous epithelial cells. This suggests that BSS might offer additional benefits beyond its antibacterial properties.
BSS's Potential to Heal Gastric Mucosa
The findings suggest that BSS may have a role in promoting the healing of damaged gastric mucosa, potentially accelerating recovery from ulcers and other gastric ailments. This is a promising discovery in the vast desert of gastrointestinal research, potentially leading to more effective treatments for stomach problems.
BSS's Potential for Gastric Health
This study suggests that BSS could be a valuable tool for promoting gastric health, offering not only antibacterial protection but also potential healing effects. This is a significant finding that may lead to a better understanding of the mechanisms underlying gastric mucosal healing and potentially to the development of more effective treatments for gastric disorders.
Dr.Camel's Conclusion
This study reveals that BSS may possess a previously unrecognized ability to promote gastric mucous epithelial cell growth, potentially contributing to the healing of gastric ulcers. This discovery is like uncovering a hidden spring in the desert of gastric health, offering a new perspective on BSS's potential therapeutic effects.
Date :
- Date Completed 2004-06-01
- Date Revised 2019-07-21
Further Info :
Related Literature
English
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