Effects of linezolid on staphylococcal adherence versus time of treatment.

Author: BuchananLewis V, DaileyCharlene F, GibsonJohn K, HaasJoseph V, PaganoPaul J, Van EnkRichard A

Paper Details 
Original Abstract of the Article :
Staphylococcus epidermidis has emerged as a major nosocomial pathogen that is often associated with infections of indwelling medical devices. Microbial adhesion to implanted foreign materials is a prerequisite for establishing infection. We studied the time-dependent anti-adhesion effects of linezol...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/15164962

データ提供:米国国立医学図書館(NLM)

Linezolid: A New Weapon Against Staphylococcal Infections

The world of bacterial infections is a vast and often unforgiving desert, with staphylococcal infections posing a significant challenge. This research investigates the potential of linezolid, an antimicrobial agent, to combat staphylococcal adherence, a crucial step in the development of device-related infections. The study explores the time-dependent anti-adhesion effects of linezolid, comparing it to vancomycin, a commonly used antibiotic. By analyzing the anti-adhesion properties of linezolid, the study seeks to identify potential strategies for preventing and treating staphylococcal infections associated with implanted medical devices.

Linezolid: A Promising Oasis in the Desert of Staphylococcal Infections

The study revealed that linezolid demonstrated potent anti-adhesion activity against Staphylococcal strains, effectively inhibiting their adherence to polystyrene surfaces. The study found that linezolid's anti-adhesion effects were evident even when administered at sub-inhibitory concentrations. Importantly, linezolid's anti-adhesion properties were sustained even when treatment was delayed by 2 and 4 hours, suggesting its potential as a prophylactic agent against device-related infections.

Preventing the Desert Bloom of Staphylococcal Infections

This research provides valuable insights into the potential of linezolid as a tool for preventing and treating staphylococcal infections, particularly those associated with implanted medical devices. The study's findings suggest that linezolid's unique anti-adhesion properties may offer a new approach to combating these infections. Further research is needed to fully understand its long-term effects and potential for human use, but the findings are a significant step forward in the fight against these challenging infections.

Dr.Camel's Conclusion

Linezolid's potent anti-adhesion properties offer a promising oasis in the desert of staphylococcal infections. The study's findings suggest that linezolid may provide a novel approach to preventing and treating these infections, particularly those associated with implanted medical devices. As we continue to explore the vast desert of antimicrobial agents, linezolid's unique characteristics make it a beacon of hope for combating the ever-present threat of staphylococcal infections.

Date :
  1. Date Completed 2004-07-02
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

15164962

DOI: Digital Object Identifier

S0924857903004059

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Languages

English

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