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Toxic effects of mebendazole at high dose on the haematology of red-legged pademelons (Thylogale stigmatica).
Author: BergerL, JohnsonP M, SkerrattL F, SpeareR
Original Abstract of the Article :
OBJECTIVE: To investigate the effects of mebendazole at high dose on the haematology of macropods. Experimental. PROCEDURE: Five red-legged pademelons (Thylogale stigmatica) were dosed orally with mebendazole at 50 mg/kg/d for 5 to 6 days. Two control pademelons were dosed with water. Regular blood...See full text at original site
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引用元:
https://doi.org/10.1111/j.1751-0813.2004.tb12710.x
データ提供:米国国立医学図書館(NLM)
Mebendazole: A Cautionary Tale for Macropod Health
Mebendazole, a commonly used antiparasitic medication, has been a valuable tool in controlling parasitic infections in various animal species. This study, like a vigilant explorer carefully observing the impact of a new substance on a delicate ecosystem, investigates the effects of high-dose mebendazole on the haematology of red-legged pademelons, a species of macropod native to Australia. The researchers documented the haematological changes experienced by these animals after receiving high doses of mebendazole, highlighting the potential risks associated with this medication.
A Delicate Balance: Mebendazole and Macropod Health
The study, like a warning sign in a desert landscape, reveals a significant risk associated with high-dose mebendazole administration in red-legged pademelons. The researchers observed severe haematological abnormalities, including leucopenia, neutropenia, thrombocytopenia, and bone marrow aplasia, leading to systemic infections and death in the treated animals. This research emphasizes the importance of careful dosing and monitoring when using mebendazole in macropods,
Navigating the Desert of Animal Health: Avoiding Unforeseen Consequences
This study serves as a reminder of the importance of considering the potential risks and benefits of any medication, especially when used in non-human species. It underscores the need for responsible and evidence-based practices in veterinary medicine, ensuring the safety and well-being of animals under our care.
Dr.Camel's Conclusion
This study highlights the importance of responsible medication use in veterinary medicine. By carefully considering the potential risks and benefits of medications, veterinarians can ensure the health and well-being of their patients, protecting them from unforeseen consequences.
Date :
- Date Completed 2004-07-02
- Date Revised 2019-12-10
Further Info :
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English
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