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Clinical applications of MAO-inhibitors.

Author: LachenmayerL, LauxG, RiedererP

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Monoamine oxidase inhibitors (MAOIs) have been used to treat psychiatric and neurological disorders for centuries. MAOIs are divided into irreversible and reversible types, with varying benefits and side effects for conditions such as Parkinson's disease, Alzheimer's dementia, depression, and panic disorders. Selegiline, an MAOI, has shown neuroprotective effects and is effective in treating Parkinson's disease. However, its metabolism to amphetamine and methamphetamine can cause cardiovascular side effects. Zydis Selegiline, a melt-tablet formulation, minimizes this metabolic conversion and offers a safer alternative. Other MAOIs, such as moclobemide, lacabemide, and rasagiline, are also being developed and have shown promising results.
Paper Details　
Original Abstract of the Article :
Monoamine oxidase inhibitors (MAO-I) have been useful in the treatment of both psychiatric and neurological disorders over centuries. Here we focus on the development of this drug treatment. Focus is given on the use of irreversible MAO-I's as well as on reversible ones. Benefit and side effects are...See full text at original site
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引用元：
https://doi.org/10.2174/0929867043364775

データ提供：米国国立医学図書館（NLM）

Monoamine Oxidase Inhibitors: A Journey Through Time in the Treatment of Psychiatric and Neurological Disorders

Monoamine oxidase inhibitors (MAO-Is) have been used for centuries to treat various psychiatric and neurological disorders. This study explores the development and clinical applications of MAO-Is, focusing on both irreversible and reversible inhibitors. The study provides a comprehensive overview of the benefits and side effects of MAO-Is in treating conditions such as Parkinson's disease, Alzheimer's dementia, depression, and panic disorders.

A Time-Tested Oasis: MAO-Is in the Treatment of Neurological and Psychiatric Disorders

The study highlights the significant role of MAO-Is in treating a wide range of neurological and psychiatric disorders. The study underscores the importance of understanding the nuances of MAO-I pharmacology and the potential for both benefits and side effects. The study also emphasizes the need for ongoing research and development to optimize the use of MAO-Is for patients.

A Journey of Discovery: The Future of MAO-I Research

This study serves as a reminder of the enduring value of MAO-Is in treating a variety of neurological and psychiatric disorders. The study highlights the importance of continued research to improve our understanding of MAO-I pharmacology and develop safer and more effective treatments. Like a camel traveling across a vast desert, we must be persistent and adaptable in our pursuit of better treatments for these conditions.

Dr. Camel's Conclusion

This research is a testament to the enduring value of MAO-Is in treating various neurological and psychiatric disorders. The study highlights the journey of MAO-I research, spanning centuries and showcasing the importance of continued exploration and innovation to develop safer and more effective treatments for these complex conditions. Like a camel navigating a vast desert, we must be persistent and adaptable in our search for better treatments for these conditions, always seeking new oases of hope for patients in need.
Date :
  1. Date Completed 2004-12-23
  2. Date Revised 2019-08-23
Further Info :

Pubmed ID

15279566

DOI: Digital Object Identifier

10.2174/0929867043364775

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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