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Clinical applications of MAO-inhibitors.

Author: LachenmayerL, LauxG, RiedererP

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Monoamine oxidase inhibitors (MAOIs) have been used to treat psychiatric and neurological disorders for centuries. MAOIs are divided into irreversible and reversible types, with varying benefits and side effects for conditions such as Parkinson's disease, Alzheimer's dementia, depression, and panic disorders. Selegiline, an MAOI, has shown neuroprotective effects and is effective in treating Parkinson's disease. However, its metabolism to amphetamine and methamphetamine can cause cardiovascular side effects. Zydis Selegiline, a melt-tablet formulation, minimizes this metabolic conversion and offers a safer alternative. Other MAOIs, such as moclobemide, lacabemide, and rasagiline, are also being developed and have shown promising results.
Paper Details　
Original Abstract of the Article :
Monoamine oxidase inhibitors (MAO-I) have been useful in the treatment of both psychiatric and neurological disorders over centuries. Here we focus on the development of this drug treatment. Focus is given on the use of irreversible MAO-I's as well as on reversible ones. Benefit and side effects are...See full text at original site
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引用元：
https://doi.org/10.2174/0929867043364775

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2004-12-23
  2. Date Revised 2019-08-23
Further Info :

Pubmed ID

15279566

DOI: Digital Object Identifier

10.2174/0929867043364775

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English

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