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Phosphodiesterase inhibitors as anti-cancer drugs.

Author: AmsterdamAbraham, DantesAda, HirshLiron, HosokawaKumiko, KotsujiFumikazu, MerimskyOfer, SuhByong-Sun, TajimaKimihisa, YoshidaYoshio

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined the effectiveness of theophylline and aminophylline, phosphodiesterase blockers that can elevate intracellular cAMP, in inducing cell death in various cancer cell lines. The results showed that theophylline synergized with cisplatin and gemcitabine to induce apoptosis, allowing for a reduction in the effective doses of these chemotherapy drugs.
Paper Details　
Original Abstract of the Article :
It is well known that high intracellular levels of cAMP can effectively kill cancer cells in vitro. Unfortunately substances elevating cAMP such as forskolin, 8-bromo-cAMP, 8-chloro-cAMP, monobutiryl or dibutiryl cAMP are not recommended to be used as anti-cancer drugs because of their high cytotoxi...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15313391

データ提供：米国国立医学図書館（NLM）

The Potential of Phosphodiesterase Inhibitors as Anti-Cancer Drugs

This research explores the intriguing world of phosphodiesterase inhibitors as potential cancer-fighting agents. The authors employed a systematic approach, utilizing a variety of carcinoma cell lines to investigate the effects of theophylline and aminophylline on cell death. Their findings indicate that these inhibitors can synergize with common anti-cancer drugs like cisplatin and gemcitabine, effectively reducing the required doses of these agents.

A Promising New Strategy in Cancer Treatment

These findings suggest that phosphodiesterase inhibitors could offer a valuable new weapon in the arsenal against cancer. The study demonstrates that theophylline, in particular, can significantly enhance the efficacy of existing chemotherapies. The researchers observed a remarkable reduction in Bcl2 levels in cancer cells, a crucial indicator of programmed cell death, or apoptosis.

A Glimpse into the Future of Cancer Treatment

This research underscores the significance of exploring new drug combinations and strategies in the fight against cancer. The potential for reducing the side effects of chemotherapy while enhancing its effectiveness is a compelling motivation for further investigation. As Dr. Camel, I am particularly excited about the possibility of utilizing natural compounds like theophylline to improve existing cancer therapies. The future of cancer treatment seems to be brimming with innovative approaches, and we may be on the verge of a new era in cancer care.

Dr.Camel's Conclusion

This study provides a compelling case for further research into the potential of phosphodiesterase inhibitors as anti-cancer drugs. The synergistic effects of these inhibitors with existing chemotherapies offer a promising avenue for improving treatment outcomes and reducing side effects. As Dr. Camel, I believe this research represents a significant step forward in our quest to develop effective and safe cancer treatments.

Date :
  1. Date Completed 2004-09-27
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15313391

DOI: Digital Object Identifier

S000629520400351X

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Article Analysis
・Side Effects of aminophylline
SNS
PICO Info
in preparation
Languages

English

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