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Interactions of benzylpenicillin and non-steroidal anti-inflammatory drugs with the sodium-dependent dicarboxylate transporter NaDC-3.

Author: BurckhardtBirgitta C, BurckhardtGerhard, LorenzJulia, SteffgenJürgen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Flufenamate and benzylpenicillin were found to inhibit the uptake of succinate in oocytes expressing fNaDC-3. Flufenamate increased K+ conductance in oocytes expressing fNaDC-3, but had no effect on water-injected control oocytes. Benzylpenicillin induced voltage-dependent inward currents in oocytes expressing fNaDC-3, but the currents were much smaller than those induced by succinate. These findings suggest that monovalent anionic drugs can interact with a transporter for divalent di- and tricarboxylates.
Paper Details　
Original Abstract of the Article :
Sodium-dependent dicarboxylate transporters located in the basolateral membrane (NaDC-3) of renal proximal tubule cells maintain the driving force for exchange of organic anions and drugs against alpha-ketoglutarate via organic anion transporters OAT1 and OAT3. So far, information on direct interact...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15319545

データ提供：米国国立医学図書館（NLM）

Exploring the Interactions of Drugs with Renal Transporters

The kidney plays a vital role in filtering waste products from the bloodstream. This study investigates the interactions of various drugs with a specific renal transporter, NaDC-3, which is responsible for maintaining the transport of organic anions and drugs. The researchers focused on the effects of non-steroidal anti-inflammatory drugs (NSAIDs) and benzylpenicillin on NaDC-3 activity.

Drug Interactions with Renal Transporters: A Balancing Act

The study found that certain NSAIDs and benzylpenicillin inhibited the activity of NaDC-3, potentially affecting drug transport and elimination. The results highlight the importance of understanding drug interactions with renal transporters to ensure safe and effective medication use. Further research is needed to determine the clinical significance of these interactions.

Navigating the Labyrinth of Drug Metabolism: A Journey Through the Kidney

This study underscores the complex interplay between drugs and renal transporters, which play a crucial role in drug elimination. Understanding these interactions is essential for optimizing drug therapy and minimizing the risk of adverse effects. This research contributes to the ever-growing knowledge base surrounding the intricacies of drug metabolism and renal function.

Dr.Camel's Conclusion

This study, like a desert traveler carefully navigating a winding path, reveals the intricate interactions between drugs and renal transporters. The findings highlight the importance of considering these interactions in the design and administration of medications, ensuring optimal therapeutic outcomes and minimizing the risk of adverse effects.
Date :
  1. Date Completed 2005-02-15
  2. Date Revised 2019-02-12
Further Info :

Pubmed ID

15319545

DOI: Digital Object Identifier

80357

SNS
PICO Info
in preparation
Languages

English

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