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Effects of drug countermeasures for space motion sickness on working memory in humans.

Author: BlakeDonna J, ChelonisJohn J, DornhofferJohn L, PauleMerle G

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Meclizine showed the best cognitive profile among the tested anti-space motion sickness (SMS) drugs, minimizing negative effects on visual working memory. Scopolamine, promethazine, and lorazepam showed greater cognitive impairments, especially in conjunction with vestibular stimulation.
Paper Details　
Original Abstract of the Article :
Space motion sickness (SMS) is a problem during the first 72 h of space flight and during transitions from different gravity environments. There currently are no effective drug countermeasures for SMS that also accommodate the retention of optimal cognitive function. This creates a dilemma for astro...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15451046

データ提供：米国国立医学図書館（NLM）

Effects of Drug Countermeasures for Space Motion Sickness on Working Memory

This research investigates the impact of drug countermeasures for space motion sickness (SMS) on working memory in humans. The study compared the cognitive effects of meclizine, scopolamine, promethazine, and lorazepam on working memory performance before and after vestibular stimulation. The results revealed that spinning alone significantly decreased task accuracy and speed, while meclizine alone had no adverse effect. Scopolamine, promethazine, and lorazepam each resulted in significant cognitive impairments, with lorazepam exhibiting the most detrimental effects. This study provides valuable insights into the cognitive side effects of potential drug countermeasures for SMS.

Finding the Right Balance for Space Travel

The research suggests that meclizine may be the most suitable drug countermeasure for SMS, offering minimal cognitive impairment. The authors' findings emphasize the need for careful consideration of cognitive side effects when selecting drug countermeasures for SMS, especially during critical phases of space travel. This research paves the way for the development of more effective and cognitively friendly countermeasures for SMS.

Living in a World of Gravity Shifts

The research highlights the complex challenges associated with space travel and the need for a comprehensive approach to addressing SMS. It's crucial to minimize exposure to factors that trigger SMS and prioritize maintaining optimal cognitive function during space missions. This research underscores the importance of continued research and development of effective and safe countermeasures for SMS.

Dr.Camel's Conclusion

This research is like a voyage across a vast and unknown desert, exploring the complex relationship between drug countermeasures and cognitive function in space travel. The authors' findings highlight the importance of finding the right balance between preventing SMS and maintaining optimal cognitive performance. As a desert-dwelling researcher, I am fascinated by the challenges faced by astronauts and the ingenuity of scientists in developing solutions. This research paves the way for a future where space travel is both safe and cognitively enriching.

Date :
  1. Date Completed 2005-02-10
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

15451046

DOI: Digital Object Identifier

S0892-0362(04)00099-6

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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