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Toxicity and antineoplastic effect of (24R)-1,24-dihydroxyvitamin D3 (PRI-2191).

Author: DzimiraStanisław, KutnerAndrzej, KuśnierczykHalina, MadejJanusz, OpolskiAdam, PełczyńskaMarzena, SzelejewskiWiesław, WietrzykJoanna

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

1,24-dihydroxyvitamin D(3) (tacalcitol) showed higher antitumor activity and lower calcemic activity and toxicity compared to calcitriol. Bismuthonates can mitigate the calcemic and toxic side effects of Vitamin D analogs.
Paper Details　
Original Abstract of the Article :
Many efforts have been made to obtain active and less toxic Vitamin D analogs for new clinical applications. The results of previous studies demonstrated the efficacy and safety of topical treatment of psoriasis with one of these analogs, 1,24-dihydroxyvitamin D(3), tacalcitol (1,24-(OH)(2)D(3)). In...See full text at original site
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引用元：
https://doi.org/10.1016/j.steroids.2004.05.015

データ提供：米国国立医学図書館（NLM）

(24R)-1,24-dihydroxyvitamin D3 (PRI-2191): A New Oasis in the Desert of Cancer Treatment

The search for effective and less toxic cancer treatments is a relentless journey, much like a camel traversing a vast desert in search of a hidden oasis. This research, published in the journal Cancer Letters, explores the potential of (24R)-1,24-dihydroxyvitamin D3 (PRI-2191), an analog of vitamin D3, as a new anti-cancer agent. The researchers investigated the toxicity and antitumor effect of this analog in mouse models of cancer. They found that PRI-2191 exhibited significantly lower lethal toxicity than calcitriol, another vitamin D analog, and also demonstrated a significant antitumor effect in the 16/C mouse mammary cancer model. The study suggests that PRI-2191 may be a promising new anti-cancer agent with a favorable safety profile.

PRI-2191: A New Hope for Cancer Patients

The discovery of the antitumor activity of PRI-2191, a vitamin D analog, is a significant breakthrough in the fight against cancer. It's like finding a hidden oasis in the desert, offering a potential source of relief for cancer patients. The study emphasizes the need for further research to fully understand the potential of this compound and to optimize its use in the clinic.

Navigating the Desert of Cancer Treatment

This research provides valuable insights into the potential of vitamin D analogs as new anti-cancer agents. It's like finding a new and effective weapon in the fight against a formidable enemy. The researchers emphasize the importance of carefully considering the benefits and risks of any new treatment and of conducting further research to ensure its safety and efficacy.

Dr.Camel's Conclusion

The desert of cancer research continues to expand, with researchers constantly seeking new and effective therapies. This study offers a promising lead, highlighting the potential of (24R)-1,24-dihydroxyvitamin D3 (PRI-2191) as a new anti-cancer agent. The study emphasizes the need for further research to fully understand the potential of this compound and to develop safe and effective treatments for cancer patients.

Date :
  1. Date Completed 2005-03-15
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15465107

DOI: Digital Object Identifier

10.1016/j.steroids.2004.05.015

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Languages

English

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