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In vitro anti-inflammatory effects and immunomodulation by gemifloxacin in stimulated human THP-1 monocytes.

Author: HallI H, IvesT, SchwabU, WardE S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Gemifloxacin, a fluoroquinolone antibiotic, was studied for its effects on human monocytes, immune cells that play a role in fighting infection. The study found that gemifloxacin stimulated phagocytosis and killing of bacteria by monocytes.
Paper Details　
Original Abstract of the Article :
Cultured human THP-1 monocytes were exposed to serial concentrations of gemifloxacin over 4 h after pre-stimulation with zymogen A for 1 h or Staphylococcus aureus for 2 h. The following parameters were assessed: pH, phagocytosis, c-AMP, NO, TNFalpha, IL-1, IL-6, IL-8 and H2O2 levels, enzyme activit...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15497755

データ提供：米国国立医学図書館（NLM）

Exploring the Anti-Inflammatory Effects of Gemifloxacin

Gemifloxacin, a fluoroquinolone antibiotic, is commonly used to treat bacterial infections. This research delves into the complex world of inflammation, investigating the anti-inflammatory effects of gemifloxacin in stimulated human THP-1 monocytes. The study explores the mechanisms by which gemifloxacin modulates inflammatory responses, providing valuable insights into its potential therapeutic applications beyond its antibacterial properties.

Gemifloxacin's Anti-Inflammatory Properties

The study found that gemifloxacin exerted both pro-inflammatory and anti-inflammatory effects in stimulated THP-1 monocytes, influencing various parameters including c-AMP, NO, H2O2, TNFalpha levels, and enzyme activities. These findings suggest that gemifloxacin may have a complex and multifaceted role in modulating inflammatory responses.

Potential Therapeutic Applications of Gemifloxacin

This research highlights the potential therapeutic applications of gemifloxacin beyond its antibacterial properties. The findings suggest that gemifloxacin's anti-inflammatory effects may have beneficial implications for managing various inflammatory conditions.

Dr.Camel's Conclusion

Imagine a desert landscape, where a fierce sandstorm symbolizes inflammation. Gemifloxacin, like a steady oasis, offers a respite from the storm, modulating inflammatory responses and potentially offering therapeutic benefits beyond its antibacterial properties. This research highlights the exciting potential of exploring the anti-inflammatory effects of antibiotics, opening up new avenues for treating inflammatory conditions.

Date :
  1. Date Completed 2004-11-29
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

15497755

DOI: Digital Object Identifier

15497755

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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