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AZT induces oxidative damage to cardiac mitochondria: protective effect of vitamins C and E.

Author: Del OlmoMaría L, Gómez-CambroneroLuis G, PallardóFederico V, SastreJuan, ViñaJosé, de la AsunciónJosé García

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

AZT (zidovudine), an antiretroviral drug used to treat HIV infection, can damage heart mitochondria. This study found that supplementing with vitamins C and E protected against AZT-induced mitochondrial damage.
Paper Details　
Original Abstract of the Article :
AZT (zidovudine) is a potent inhibitor of HIV replication and a major antiretroviral drug used for AIDS treatment. A major limitation in the use of AZT is the occurrence of severe side effects. The aim of this work was to test whether AZT causes oxidative damage to heart mitochondria and whether thi...See full text at original site
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引用元：
https://doi.org/10.1016/j.lfs.2004.06.020

データ提供：米国国立医学図書館（NLM）

The Impact of AZT on Cardiac Mitochondria

This study takes us into the heart of the matter, exploring the effects of AZT (zidovudine), a crucial drug for treating HIV, on cardiac mitochondria. Imagine the desert as a complex network of cells, each playing a vital role in keeping the body functioning. AZT is a powerful tool in the fight against HIV, but it can also have side effects, including damage to the heart. This study investigates whether AZT causes oxidative damage to heart mitochondria and whether this damage can be prevented by antioxidant vitamins. The study found that AZT treatment led to increased oxidative damage in heart mitochondria, but this damage could be mitigated by supplemental doses of vitamins C and E.

Protecting the Heart While Fighting HIV

This research provides valuable insights into the potential cardiotoxicity of AZT, a vital drug in HIV treatment. The study highlights the importance of antioxidants in protecting cardiac mitochondria from oxidative damage caused by AZT.

Balancing the Benefits and Risks

This study emphasizes the need to balance the benefits and risks of AZT treatment. The findings encourage clinicians to consider the potential for cardiac side effects and the protective role of antioxidant vitamins.

Dr.Camel's Conclusion

This study delves into the impact of AZT on cardiac mitochondria, revealing the potential for oxidative damage. The research highlights the protective role of antioxidants, such as vitamins C and E, in mitigating this damage. It's a reminder that even with powerful tools like AZT, we must remain vigilant about potential side effects and explore ways to minimize their impact.

Date :
  1. Date Completed 2004-12-21
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

15501479

DOI: Digital Object Identifier

10.1016/j.lfs.2004.06.020

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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