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Mast cell-dependent control of Giardia lamblia infections in mice.

Author: LiErqiu, PetrinZiva, SingerSteven M, ZhouPing

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Mast cells are important for immune response to parasites and are also involved in allergic diseases. This study found that mast cells play a critical role in the rapid control of Giardia infections in mice. The study also found that IL-6 is not necessary for mast cell responses, but mast cell production of IL-6 appears to be important for controlling Giardia infections.
Paper Details　
Original Abstract of the Article :
Mast cells are important for protective immunity to intestinal helminth infections and as mediators of allergic disease. Their role in protozoan infections is less well described. We have therefore analyzed mast cell responses and parasite control in mice infected with the protozoan Giardia lamblia....See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC523017/

データ提供：米国国立医学図書館（NLM）

Mast Cells and Giardia: A Complex Immune Response

Giardia lamblia is a protozoan parasite that can cause gastrointestinal illness in humans. This study, published in the Journal of Immunology, investigates the role of mast cells in the immune response to Giardia infection in mice. Mast cells are immune cells that play a role in allergic reactions and defense against parasites.

Mast Cells in Giardia Infection

The study found that mast cells are crucial for the rapid control of Giardia infection in mice. Mice lacking mast cells were unable to mount a protective immune response and eliminate the infection. The authors also found that mast cell activation and the production of interleukin-6 (IL-6) were important for controlling the infection.

The Importance of IL-6 in Giardia Immunity

The study provides evidence for the role of IL-6 in the immune response to Giardia infection. IL-6 is a cytokine that plays a role in inflammation and immune regulation. The authors found that IL-6-deficient mice had enhanced mast cell responses but failed to control the infection, suggesting that IL-6 production by mast cells is important for effective parasite clearance.

Dr. Camel's Conclusion

The immune system is a complex network of cells and molecules that work together to defend the body against invaders. This study provides fascinating insights into the role of mast cells in the immune response to Giardia infection. The findings highlight the importance of IL-6 in mast cell function and parasite control, emphasizing the intricate interplay between different immune components.

Date :
  1. Date Completed 2004-12-02
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

15501797

DOI: Digital Object Identifier

PMC523017

Related Literature

Article Analysis
・Effective treatment of giardia infections
SNS
PICO Info
in preparation
Languages

English

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