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Stabilization of rasburicase and physico-chemical characterization of the resulting injectable formulation.
Author: AlemanC, BauerMichel, BayolAlain, BonnetMarie Claude, BreulThierry, DupinPatrice, DuplaaHélène, FaurePhilippe, MenegottoJérome
Original Abstract of the Article :
Rasburicase (Fasturtec/Elitek) is a new generation of recombinant urate oxidase administred therapeutically by intravenous infusion for the prevention or treatment of hyperuricemia during chemotherapy. To ensure a long storage period, a freeze-dried formulation was developed to guarantee the molecul...See full text at original site
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引用元:
https://doi.org/10.1081/ddc-200034582
データ提供:米国国立医学図書館(NLM)
Stabilizing Rasburicase: A Formulation for Long-Term Storage
The field of [pharmaceutical development] is constantly striving to improve the [stability and efficacy] of [medications]. This research focuses on [rasburicase], a recombinant urate oxidase used in [the treatment of hyperuricemia during chemotherapy]. The study aims to develop a [stable freeze-dried formulation] that ensures the [molecular integrity and enzyme activity] of [rasburicase], extending its [storage period]. The authors utilized [preformulation studies and experimental design] to identify the [optimal formulation] for [freeze-drying rasburicase], ensuring its [stability and effectiveness] over time. This research represents a significant contribution to the field of [pharmaceutical development], ensuring the [safe and effective] delivery of [rasburicase] to patients in need.
A Stable Formulation for Rasburicase: Ensuring Therapeutic Efficacy
This research highlights the importance of [formulation development] in [enhancing the stability and effectiveness of medications]. By optimizing the [freeze-drying process] for [rasburicase], the study ensures the [long-term stability and therapeutic efficacy] of this crucial medication. This development holds significant implications for [patient care], ensuring the [consistent availability and effectiveness] of [rasburicase] for patients undergoing chemotherapy.
Rasburicase: A Stable Solution for Hyperuricemia
The challenge of [hyperuricemia] during chemotherapy is a real one, and this research offers a solution. By developing a [stable freeze-dried formulation] for [rasburicase], the study ensures the [reliable and consistent delivery] of this crucial medication to patients. This advance in [pharmaceutical development] contributes to [improved patient care], providing a [stable and effective] treatment option for [hyperuricemia] associated with chemotherapy.
Dr. Camel's Conclusion
Just as a camel adapts to the harsh desert climate, pharmaceutical scientists are constantly adapting and innovating to ensure the stability and effectiveness of medications. This research demonstrates a significant advancement in formulation development, ensuring the long-term stability of rasburicase, a critical medication for managing hyperuricemia during chemotherapy. This stable formulation, like a reliable oasis in the desert, provides a consistent and effective treatment option for patients in need.
Date :
- Date Completed 2005-02-02
- Date Revised 2019-09-22
Further Info :
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