Ziprasidone suppresses olanzapine-induced increases in ingestive behaviour in the rat.

Author: JonesDeclan N C, KirkShona L, NeillJoanna C, ReynoldsGavin P

Paper Details 
Original Abstract of the Article :
Many atypical antipsychotic drugs, such as olanzapine, induce significant weight gain. However, ziprasidone produces minimal weight gain, the mechanism of which remains unclear. The aim of the present study was to investigate whether ziprasidone would reduce the acute effect of olanzapine on feeding...See full text at original site
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引用元:
https://doi.org/10.1016/j.ejphar.2004.10.015

データ提供:米国国立医学図書館(NLM)

Ziprasidone: A Shield Against Olanzapine-Induced Weight Gain

The [desert of antipsychotic medication] is often riddled with [undesirable side effects], including [weight gain]. This study examines the potential of [ziprasidone] to mitigate the [weight gain] associated with [olanzapine], a common atypical antipsychotic. The researchers investigated the effects of [ziprasidone] on [feeding behavior] in rats treated with [olanzapine]. Their findings revealed that [ziprasidone effectively suppressed the olanzapine-induced increases in food intake], suggesting that it might offer a [protective mechanism] against [drug-induced weight gain].

Ziprasidone: A Promising Strategy for Weight Management

This study, like a desert traveler seeking a safe haven, highlights the potential of [ziprasidone] as a [protective agent] against [olanzapine-induced weight gain]. The researchers observed that [ziprasidone significantly reduced the olanzapine-induced increase in food intake], suggesting its potential for [effective weight management] in patients taking olanzapine. The study’s findings encourage further research to explore the mechanisms underlying this effect and to determine its clinical implications.

Ziprasidone: A Potential Solution to Drug-Induced Weight Gain

This study offers a glimmer of hope in the desert of [drug-induced weight gain], suggesting that [ziprasidone] might be a valuable tool for [managing this challenging side effect]. The findings highlight the importance of [understanding the mechanisms underlying drug-induced weight gain] and exploring [alternative approaches] to minimize this adverse effect. Further research is needed to confirm the effectiveness of [ziprasidone] in humans and to assess its potential for [long-term weight management] in patients taking [olanzapine].

Dr.Camel's Conclusion

This research suggests that ziprasidone may offer a protective mechanism against olanzapine-induced weight gain by suppressing olanzapine-induced increases in food intake. The study’s findings encourage further research to explore the clinical implications of ziprasidone in managing drug-induced weight gain, potentially providing a valuable tool for patients taking olanzapine.

Date :
  1. Date Completed 2005-05-16
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

15556160

DOI: Digital Object Identifier

10.1016/j.ejphar.2004.10.015

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SNS
PICO Info
in preparation
Languages

English

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