Paper Details

  1. Home
  2. Paper Details

The clinical impact of thiopurine methyltransferase polymorphisms on thiopurine treatment.

Author: CoulthardS A, HallA G, HogarthL A, MathesonE C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This article discusses the genetic basis of thiopurine metabolism and its importance in treating acute lymphoblastic leukemia. Thiopurines are effective in preventing relapse but can cause severe side effects if patients have low thiopurine methyltransferase (TPMT) activity.
Paper Details　
Original Abstract of the Article :
Acute lymphoblastic leukaemia (ALL) is the most common malignancy of childhood. Although current treatment results in long term survival in over 70% of cases there is evidence that as many as 50% could have been cured using a less complex regimen with a lower incidence of long term side effects. In ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1081/NCN-200027637

データ提供：米国国立医学図書館（NLM）

Thiopurine Methyltransferase Polymorphisms: Personalized Medicine for ALL Treatment

Acute lymphoblastic leukemia (ALL) is a serious childhood cancer. This study explores the impact of thiopurine methyltransferase (TPMT) polymorphisms on the effectiveness of thiopurine treatment for ALL. TPMT is an enzyme that plays a crucial role in metabolizing thiopurine drugs, which are key components of ALL treatment. Variations in TPMT activity, often due to genetic polymorphisms, can significantly affect the efficacy and safety of thiopurine therapy.

Tailoring Treatment: The Importance of TPMT Polymorphisms

The study highlights the importance of considering TPMT polymorphisms when prescribing thiopurine drugs for ALL treatment. By understanding an individual's TPMT activity, healthcare providers can tailor treatment regimens to optimize efficacy and minimize the risk of adverse effects. Imagine, if you will, TPMT polymorphisms as a map of the desert, guiding healthcare providers to navigate the diverse terrain of individual patient responses to thiopurine therapy.

Personalized Medicine in Action: Optimizing Treatment for ALL

This study underscores the importance of personalized medicine approaches for treating ALL. By considering individual genetic variations, healthcare providers can optimize treatment strategies and improve outcomes for patients. This research represents a step towards a future where medicine is tailored to each individual's unique needs, ensuring that the right treatment is given at the right dose, just as a skilled camel guide carefully navigates the desert, ensuring the safe and efficient delivery of supplies.

Dr.Camel's Conclusion

This study emphasizes the importance of personalized medicine in optimizing treatment for ALL. By considering TPMT polymorphisms, healthcare providers can tailor treatment regimens to individual patients, improving efficacy and minimizing side effects. It's a reminder that even in the vast desert of medical challenges, understanding individual differences can lead to better outcomes for patients.

Date :
  1. Date Completed 2005-02-03
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

15571264

DOI: Digital Object Identifier

10.1081/NCN-200027637

Related Literature

Article Analysis
・Side Effects of thioguanine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.