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Challenges and new discoveries in the treatment of leishmaniasis.

Author: SinghSarman, SivakumarRamu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Leishmaniasis is a parasitic disease that affects 88 countries and has 4 common forms. There are 25 compounds for treating it, but most are injected and some have toxic side effects. Oral drugs are being researched to avoid complications, such as miltefosine, which is 94%-97% effective but cannot be used during pregnancy and has gastrointestinal side effects. Combination therapies with enzyme inhibitors are needed.
Paper Details　
Original Abstract of the Article :
Leishmaniasis is a parasitic disease caused by a hemoflagellate, Leishmania spp. The parasite is transmitted by the bite of an infected female phlebotomine sandfly. The disease is prevalent throughout the world and in at least 88 countries. Human leishmanial infections may manifest in any of the fou...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/15614453

データ提供：米国国立医学図書館（NLM）

Leishmaniasis: A Fight Against a Parasitic Invader

This research takes us on a journey into the world of leishmaniasis, a parasitic disease that affects millions worldwide. It's like a battle in a desert, where the parasite, Leishmania spp., seeks to conquer the human body. This study explores the challenges and new discoveries in the treatment of this disease, highlighting the ongoing search for effective and safe therapies.

A Quest for New Weapons in the Desert

The study reviews a wide range of antileishmanial compounds, highlighting the successes and limitations of current treatments. While significant progress has been made, particularly with the development of oral medications like miltefosine, the fight against leishmaniasis remains complex and requires continued research. The study emphasizes the need for combination therapies and the development of specific parasite enzyme inhibitors to further enhance treatment options.

Navigating the Sands of Leishmaniasis Treatment

This study serves as a valuable guide for those seeking information about leishmaniasis treatment. It highlights the challenges and successes in the field, offering hope for improved treatment outcomes. The ongoing research, like a camel caravan navigating the sands, is constantly searching for new and effective therapies to combat this parasitic disease.

Dr.Camel's Conclusion

The battle against leishmaniasis is a long and challenging journey, but research continues to provide new weapons and strategies. This study reminds us that progress is possible, but vigilance, collaboration, and a relentless pursuit of new therapies are crucial to ultimately conquer this desert of disease.

Date :
  1. Date Completed 2005-01-27
  2. Date Revised 2018-05-09
Further Info :

Pubmed ID

15614453

DOI: Digital Object Identifier

S1341-321X(04)71028-4

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Languages

English

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